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- W2752998074 abstract "For many years the application of immune therapy to multiple myeloma (MM), with the limited exception of allogeneic stem cell transplantation, lagged behind other hematologic malignancies. However, the introduction of immune-modulating drugs (e.g. lenalidomide, pomalidomide), which have multiple anti-neoplastic properties, opened an era where the role of immune therapy plays an important and growing role in the treatment of newly diagnosed and relapsed/refractory (RR) MM. Recently, monoclonal antibodies targeting CD38 (daratumumab) and SLAMF-7 (elotuzumab) have received approval for RR MM. Similarly the demonstration that that PD-L1 is commonly overexpressed by myeloma tumor cells has led to the introduction of checkpoint inhibitors into clinical trials. Adoptive cellular therapies including marrow infiltrating lymphocytes and T cells modified with chimeric antigen receptors targeting a variety of antigens (e.g. CD19, CD38, BCMA) have resulted in highly encouraging results in early clinical trials. Ultimately, the greatest potential for improved efficacy will come from combining each of these modalities either with currently existing therapies or more likely with other immune therapies." @default.
- W2752998074 created "2017-09-15" @default.
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- W2752998074 date "2017-09-01" @default.
- W2752998074 modified "2023-10-17" @default.
- W2752998074 title "Immune Therapy for Multiple Myeloma" @default.
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- W2752998074 doi "https://doi.org/10.1016/j.clml.2017.08.065" @default.
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