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- W2753008210 abstract "The prohormone VGF is expressed in neuroendocrine and endocrine tissues and regulates nutrient and energy status both centrally and peripherally. We and others have shown that VGF-derived peptides have direct action on the islet β cell as secretagogues and cytoprotective agents; however, the endogenous function of VGF in the β cell has not been described. Here, we demonstrate that VGF regulates secretory granule formation. VGF loss-of-function studies in both isolated islets and conditional knockout mice reveal a profound decrease in stimulus-coupled insulin secretion. Moreover, VGF is necessary to facilitate efficient exit of granule cargo from the trans-Golgi network and proinsulin processing. It also functions to replenish insulin granule stores following nutrient stimulation. Our data support a model in which VGF operates at a critical node of granule biogenesis in the islet β cell to coordinate insulin biosynthesis with β cell secretory capacity." @default.
- W2753008210 created "2017-09-15" @default.
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- W2753008210 date "2017-09-01" @default.
- W2753008210 modified "2023-10-10" @default.
- W2753008210 title "The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis" @default.
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- W2753008210 doi "https://doi.org/10.1016/j.celrep.2017.08.050" @default.
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