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- W2753056095 abstract "The catalytic activity of enzymes produced by an entomopathogenic filamentous fungus (Isaria fumosorosea KCh J2) towards selected steroid compounds (androstenedione, adrenosterone, progesterone, 17α-methyltestosterone and dehydroepiandrosterone) was investigated. All tested substrates were efficiently transformed. The structure of the substrate has a crucial impact on regio- and stereoselectivity of hydroxylation since it affects binding to the active site of the enzyme. Androstenedione was hydroxylated in the 7α-position to give a key intermediate in the synthesis of the diuretic-7α-hydroxyandrost-4-ene-3,17-dione with 82% conversion. Adrenosterone and 17α-methyltestosterone were hydroxylated in the 6β-position. Hydroxylated derivatives such as 15β-hydroxy-17α-methyltestosterone and 6β,12β-dihydroxy-17α-methyltestosterone were also observed. In the culture of Isaria fumosorosea KCh J2, DHEA was effectively hydroxylated in the C-7 position and then oxidized to give 7-oxo-DHEA, 3β,7α- and 3β,7β-dihydroxy-17a-oxa-d-homo-androst-5-ene-17-one. We obtained 7β-OH-DHEA lactone with 82% yield during 3 days transformation of highly concentrated (5 g/L) DHEA." @default.
- W2753056095 created "2017-09-15" @default.
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- W2753056095 date "2017-09-09" @default.
- W2753056095 modified "2023-09-28" @default.
- W2753056095 title "Isaria fumosorosea KCh J2 Entomopathogenic Strain as an Effective Biocatalyst for Steroid Compound Transformations" @default.
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- W2753056095 doi "https://doi.org/10.3390/molecules22091511" @default.
- W2753056095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6151793" @default.
- W2753056095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28891949" @default.
- W2753056095 hasPublicationYear "2017" @default.
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