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- W2753104575 abstract "Abstract TFIID binds promoter DNA to recruit RNA polymerase II and other basal factors for transcription. Although the TATA-Binding Protein (TBP) subunit of TFIID is necessary and sufficient for in vitro transcription, the TBP-Associated Factor (TAF) subunits recognize downstream promoter elements, act as co-activators, and interact with nucleosomes. Here we show that transcription induces stable TAF binding to downstream promoter DNA, independent of upstream contacts, TBP, or other basal transcription factors. This transcription-dependent TAF complex promotes subsequent activator-independent transcription, and promoter response to TAF mutations in vivo correlates with the level of downstream, rather than overall, Taf1 crosslinking. We propose a new model in which TAFs function as reinitiation factors, accounting for the differential responses of promoters to various transcription factor mutations." @default.
- W2753104575 created "2017-09-15" @default.
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- W2753104575 date "2017-09-04" @default.
- W2753104575 modified "2023-09-22" @default.
- W2753104575 title "Downstream promoter interactions of TFIID TAFs facilitate transcription reinitiation" @default.
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- W2753104575 doi "https://doi.org/10.1101/184317" @default.
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