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- W2753109313 endingPage "e3045" @default.
- W2753109313 startingPage "e3045" @default.
- W2753109313 abstract "Abstract Effective management of breast cancer depends on early diagnosis and proper monitoring of patients’ response to therapy. However, these goals are difficult to achieve because of the lack of sensitive and specific biomarkers for early detection and for disease monitoring. Accumulating evidence in the past several years has highlighted the potential use of peripheral blood circulating nucleic acids such as DNA, mRNA and micro (mi)RNA in breast cancer diagnosis, prognosis and for monitoring response to anticancer therapy. Among these, circulating miRNA is increasingly recognized as a promising biomarker, given the ease with which miRNAs can be isolated and their structural stability under different conditions of sample processing and isolation. In this review, we provide current state-of-the-art of miRNA biogenesis, function and discuss the advantages, limitations, as well as pitfalls of using circulating miRNAs as diagnostic, prognostic or predictive biomarkers in breast cancer management." @default.
- W2753109313 created "2017-09-15" @default.
- W2753109313 creator A5011905144 @default.
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- W2753109313 creator A5091741741 @default.
- W2753109313 date "2017-09-07" @default.
- W2753109313 modified "2023-10-16" @default.
- W2753109313 title "Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers" @default.
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