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• W2753166122 abstract "Abstract Aim Although sporadic colorectal cancer (CRC) usually occurs in patients aged over 50, recent evidence suggests that the incidence is increasing in younger patients. Such patients are theoretically at high risk of metachronous neoplasia and may be candidates for extended prophylactic colectomy. This study aimed to define the risk of metachronous cancer/adenomas during follow‐up of younger patients who underwent segmental colectomy for CRC. Method A CRC database was used to identify patients aged under 50 who underwent surgery for CRC between 1994 and 2010. Patients diagnosed with hereditary cancer or inflammatory bowel disease were excluded. The primary end‐points were frequency of extended resection and the rates of metachronous cancer and high‐risk adenomas during follow‐up. Results There were 284 young patients with a resectable primary tumour, of whom 280 (98.6%) underwent segmental resection, 3 (1%) extended resection and 1 (0.4%) local resection. Endoscopic follow‐up was available for 150 of the patients who had segmental colectomy, with a mean age of 42.6 (±5.8) years at diagnosis and median follow‐up time of 68 months (interquartile range 45–105). Out of these 150 patients, 4 (2.7%) developed metachronous colonic adenocarcinoma at 24, 71, 151 and 228 months after index surgery. Thirty additional patients had at least one adenoma identified during surveillance, and three had sessile serrated polyps. Out of the three patients undergoing extended resection, none had metachronous cancer or advanced adenomas at an average follow‐up of 17 years. Conclusion A segmental colectomy or proctectomy is adequate treatment for patients presenting with CRC under the age of 50." @default.
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• W2753166122 date "2017-11-01" @default.
• W2753166122 modified "2023-10-02" @default.
• W2753166122 title "Colorectal surveillance after segmental resection for young-onset colorectal cancer: is there evidence for extended resection?" @default.
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• W2753166122 doi "https://doi.org/10.1111/codi.13874" @default.
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