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- W2753171978 abstract "BACKGROUND Endothelial cell damage and glycocalyx shedding after trauma can increase the risk of inflammation, coagulopathy, vascular permeability, and death. Bedside sublingual video-microscopy may detect worse flow and perfusion associated with this endotheliopathy. We compared markers of endotheliopathy with physical flow dynamics after traumatic hemorrhagic shock. METHODS Sublingual incident dark field video-microscopy was performed at three time points after injury (<10 hours, 10–30 hours, and 30–50 hours). Values for microcirculatory flow index (MFI), Point Of carE Microcirculation assessment (POEM) score, proportion of perfused vessels (PPV), microcirculatory heterogeneity index (MHI), perfused vessel density (PVD), and total vessel density (TVD) were obtained. ELISAs were performed to measure concentrations of thrombomodulin and syndecan-1 as biomarkers of endothelial cell damage and glycocalyx shedding respectively. Flow parameters were dichotomized to above and below average, and biomarkers compared between groups; below average MFI, POEM, PPV, PVD, and TVD, and above average MHI were considered poor microcirculatory flow dynamics. RESULTS A total of 155 sublingual video-microscopy clips corresponding to 39 time points from 17 trauma patients were analyzed. Median age was 35 (IQR 25–52); 16/17 were men. Within 10 hours of injury, syndecan-1 concentrations were significantly higher compared to 17 age- and sex-matched healthy controls (30 [IQR 20–44] ng/mL) for worse TVD (78 [IQR 63–417] ng/mL), PVD (156 [IQR 63–590] ng/mL), PPV (249 [IQR 64–578] ng/mL), MFI (249 [IQR 64–578] ng/mL), MHI (45 [IQR] 38–68) ng/mL), and POEM scores (108 [IQR 44–462] ng/mL) (all p < 0.01). Thrombomodulin was also raised within 10 hours of injury when compared to healthy controls (2.9 [IQR 2.2–3.4] ng/mL) for worse PPV (4.1 [IQR 3.4–6.2] ng/mL) and MFI (4.1 [IQR 3.4–6.2] ng/mL) (both p < 0.05). CONCLUSIONS Endothelial cell damage and glycocalyx shedding are associated with worse flow, density, and heterogeneity within microvessels after traumatic hemorrhagic shock. The clinical utility of these biomarkers and flow parameters at the bedside are yet to be elucidated. LEVEL OF EVIDENCE Prognostic study, level III." @default.
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- W2753171978 date "2018-01-01" @default.
- W2753171978 modified "2023-10-16" @default.
- W2753171978 title "Poor microcirculatory flow dynamics are associated with endothelial cell damage and glycocalyx shedding after traumatic hemorrhagic shock" @default.
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- W2753171978 doi "https://doi.org/10.1097/ta.0000000000001695" @default.
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