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- W2753175045 abstract "Angiomotin ( AMOT ) promotes angiogenesis and plays a role in neovascularization during tumorigenesis. Recently, the AMOT isoform, AMOT ‐p130, was shown to exert a regulatory effect on Yes‐associated protein 1 ( YAP 1), a major downstream effector of the Hippo pathway. The specific roles of AMOT ‐p130 and YAP 1 in advanced gastric cancer ( AGC ) are yet to be established. In this study, a total of 166 patients with AGC were enrolled, and AMOT ‐p130 and YAP 1 levels were analyzed by immunohistochemistry using tissue microarrays. Low AMOT ‐p130 together with high YAP 1 expression (n = 30, 18.1%) was associated with high T stage (p = 0.042), high TNM stage (p = 0.025), and venous invasion (p = 0.048). A Kaplan–Meier survival analysis with log‐rank test revealed a significant correlation with decreased AMOT ‐p130 coupled with high nuclear YAP 1 expression with shorter overall survival (p = 0.0045) and disease‐free survival (p = 0.0028). Furthermore, multivariate analyses showed that the low AMOT ‐p130/high YAP 1 expression profile was an independent prognostic factor for disease‐free survival (p = 0.008, HR = 1.874, CI , 1.177–2.986) and overall survival (p = 0.012, HR = 1.903, CI , 1.152–3.143). Our findings collectively demonstrate that low AMOT ‐p130 combined with high YAP 1 expression is correlated with an unfavorable AGC prognosis." @default.
- W2753175045 created "2017-09-15" @default.
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- W2753175045 date "2017-09-08" @default.
- W2753175045 modified "2023-10-01" @default.
- W2753175045 title "Low angiomotin‐p130 with concomitant high Yes‐associated protein 1 expression is associated with adverse prognosis of advanced gastric cancer" @default.
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- W2753175045 doi "https://doi.org/10.1111/apm.12750" @default.
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