FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2753223721> ?p ?o ?g. }

• W2753223721 endingPage "286" @default.
• W2753223721 startingPage "281" @default.
• W2753223721 abstract "Bronchiectasis is a heterogeneous entity, taking into account clinical characteristics, inflammatory response, effectiveness of treatment and frequency of exacerbations. In stable state non-cystic fibrosis (non-CF) bronchiectasis, little is known about non-invasive techniques used for evaluating airway inflammation in obstructive airway diseases.We sought to evaluate the associations between induced sputum and clinical/radiologic characteristics, and the differences between biomarkers expressing Th1 and Th2 response in patients with non-CF bronchiectasis and to compare our findings with a previously studied population of patients with asthma and COPD.We evaluated prospectively collected data from subjects with bronchiectasis. Comparisons were made between clinical, radiographic and physiologic characteristics, as well as induced sputum markers using appropriate statistical tools. We compared the levels of sputum markers with those of a previously studied cohort of asthma and COPD patients.We enrolled 40 subjects (21men, mean age 63.5yrs) with bronchiectasis. Fifteen subjects (37.5%) had a neutrophilic phenotype, 7 (17.5%) had an eosinophilic phenotype, 3 (12.5%) had a mixed neutrophilic-eosinophilic phenotype and 15 (37.5%) had a paucigranulocytic phenotype. Subjects with sputum neutrophilia had more severe bronchiectasis in HRCT and higher levels of IL-8 in sputum, whereas subjects with eosinophilia had higher levels of FeNO, greater bronchodilator reversibility and higher sputum IL-13. Sputum IL-8 levels were higher in subjects exhibiting frequent exacerbations and correlated with neutrophils in sputum (r=0.799), the extent of bronchiectasis in HRCT (r=0.765) and post-bronchodilator FEV1 (r=-0.416). Sputum IL-13 levels correlated with sputum eosinophils (r=0.656) and bronchodilator reversibility (r=0.441). Neutrophilic bronchiectasis exhibited comparable IL-8 levels to COPD, whereas eosinophilic bronchiectasis showed significantly lower IL-13 levels compared to asthma.Sputum cell counts and IL-8 and IL-13 correlate with distinct clinical and functional measurements of disease severity and therefore may have a role for non-invasively assessing inflammation in non-cystic fibrosis bronchiectasis." @default.
• W2753223721 created "2017-09-15" @default.
• W2753223721 creator A5010301737 @default.
• W2753223721 creator A5039311118 @default.
• W2753223721 creator A5046774961 @default.
• W2753223721 creator A5048940805 @default.
• W2753223721 creator A5050668541 @default.
• W2753223721 creator A5057623122 @default.
• W2753223721 creator A5064085023 @default.
• W2753223721 creator A5069201592 @default.
• W2753223721 creator A5076353213 @default.
• W2753223721 creator A5078637828 @default.
• W2753223721 date "2017-11-01" @default.
• W2753223721 modified "2023-10-11" @default.
• W2753223721 title "The role of non-invasive modalities for assessing inflammation in patients with non-cystic fibrosis bronchiectasis" @default.
• W2753223721 cites W1544230351 @default.
• W2753223721 cites W1968523410 @default.
• W2753223721 cites W1974195573 @default.
• W2753223721 cites W1976858537 @default.
• W2753223721 cites W2032819542 @default.
• W2753223721 cites W2055088282 @default.
• W2753223721 cites W2067307039 @default.
• W2753223721 cites W2091889276 @default.
• W2753223721 cites W2100804812 @default.
• W2753223721 cites W2103360999 @default.
• W2753223721 cites W2108105410 @default.
• W2753223721 cites W2108865351 @default.
• W2753223721 cites W2109781176 @default.
• W2753223721 cites W2111407500 @default.
• W2753223721 cites W2118858765 @default.
• W2753223721 cites W2125132929 @default.
• W2753223721 cites W2131125812 @default.
• W2753223721 cites W2132977697 @default.
• W2753223721 cites W2134338459 @default.
• W2753223721 cites W2138563820 @default.
• W2753223721 cites W2141835187 @default.
• W2753223721 cites W2149588950 @default.
• W2753223721 cites W2153734927 @default.
• W2753223721 cites W2156081300 @default.
• W2753223721 cites W2163761940 @default.
• W2753223721 cites W2233830579 @default.
• W2753223721 cites W2305426319 @default.
• W2753223721 cites W2327562030 @default.
• W2753223721 cites W2341948965 @default.
• W2753223721 cites W2345335473 @default.
• W2753223721 cites W2604596332 @default.
• W2753223721 cites W4211006694 @default.
• W2753223721 cites W4231910723 @default.
• W2753223721 cites W4254139948 @default.
• W2753223721 doi "https://doi.org/10.1016/j.cyto.2017.08.005" @default.
• W2753223721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28863927" @default.
• W2753223721 hasPublicationYear "2017" @default.
• W2753223721 type Work @default.
• W2753223721 sameAs 2753223721 @default.
• W2753223721 citedByCount "54" @default.
• W2753223721 countsByYear W27532237212018 @default.
• W2753223721 countsByYear W27532237212019 @default.
• W2753223721 countsByYear W27532237212020 @default.
• W2753223721 countsByYear W27532237212021 @default.
• W2753223721 countsByYear W27532237212022 @default.
• W2753223721 countsByYear W27532237212023 @default.
• W2753223721 crossrefType "journal-article" @default.
• W2753223721 hasAuthorship W2753223721A5010301737 @default.
• W2753223721 hasAuthorship W2753223721A5039311118 @default.
• W2753223721 hasAuthorship W2753223721A5046774961 @default.
• W2753223721 hasAuthorship W2753223721A5048940805 @default.
• W2753223721 hasAuthorship W2753223721A5050668541 @default.
• W2753223721 hasAuthorship W2753223721A5057623122 @default.
• W2753223721 hasAuthorship W2753223721A5064085023 @default.
• W2753223721 hasAuthorship W2753223721A5069201592 @default.
• W2753223721 hasAuthorship W2753223721A5076353213 @default.
• W2753223721 hasAuthorship W2753223721A5078637828 @default.
• W2753223721 hasConcept C126322002 @default.
• W2753223721 hasConcept C142724271 @default.
• W2753223721 hasConcept C203014093 @default.
• W2753223721 hasConcept C2776042228 @default.
• W2753223721 hasConcept C2776301714 @default.
• W2753223721 hasConcept C2776780178 @default.
• W2753223721 hasConcept C2776938444 @default.
• W2753223721 hasConcept C2777129736 @default.
• W2753223721 hasConcept C2777714996 @default.
• W2753223721 hasConcept C2777802486 @default.
• W2753223721 hasConcept C2779379686 @default.
• W2753223721 hasConcept C2779758542 @default.
• W2753223721 hasConcept C2780333948 @default.
• W2753223721 hasConcept C2781018748 @default.
• W2753223721 hasConcept C2781069245 @default.
• W2753223721 hasConcept C2908647359 @default.
• W2753223721 hasConcept C71924100 @default.
• W2753223721 hasConcept C90924648 @default.
• W2753223721 hasConcept C99454951 @default.
• W2753223721 hasConceptScore W2753223721C126322002 @default.
• W2753223721 hasConceptScore W2753223721C142724271 @default.
• W2753223721 hasConceptScore W2753223721C203014093 @default.
• W2753223721 hasConceptScore W2753223721C2776042228 @default.
• W2753223721 hasConceptScore W2753223721C2776301714 @default.
• W2753223721 hasConceptScore W2753223721C2776780178 @default.
• W2753223721 hasConceptScore W2753223721C2776938444 @default.

• next