Matches in SemOpenAlex for { <https://semopenalex.org/work/W2753241897> ?p ?o ?g. }
- W2753241897 abstract "Abstract Excessive reactive oxygen species (ROS) can damage proteins, lipids, and DNA, which result in cell damage and death. The outcomes can be acute, as seen in stroke, or more chronic as observed in age-related diseases such as Parkinson’s disease. Here we investigate the antioxidant ability of a novel synthetic flavonoid, Proxison (7-decyl-3-hydroxy-2-(3,4,5-trihydroxyphenyl)-4-chromenone), using a range of in vitro and in vivo approaches. We show that, while it has radical scavenging ability on par with other flavonoids in a cell-free system, Proxison is orders of magnitude more potent than natural flavonoids at protecting neural cells against oxidative stress and is capable of rescuing damaged cells. The unique combination of a lipophilic hydrocarbon tail with a modified polyphenolic head group promotes efficient cellular uptake and moderate mitochondrial enrichment of Proxison. Importantly, in vivo administration of Proxison demonstrated effective and well tolerated neuroprotection against cell loss in a zebrafish model of dopaminergic neurodegeneration." @default.
- W2753241897 created "2017-09-15" @default.
- W2753241897 creator A5026231109 @default.
- W2753241897 creator A5034529744 @default.
- W2753241897 creator A5040875680 @default.
- W2753241897 creator A5042249371 @default.
- W2753241897 creator A5053139893 @default.
- W2753241897 creator A5057119874 @default.
- W2753241897 creator A5061800712 @default.
- W2753241897 creator A5081370735 @default.
- W2753241897 creator A5081747194 @default.
- W2753241897 date "2017-09-19" @default.
- W2753241897 modified "2023-09-26" @default.
- W2753241897 title "A synthetic cell permeable antioxidant protects neurons against acute oxidative stress" @default.
- W2753241897 cites W1261198562 @default.
- W2753241897 cites W1484882395 @default.
- W2753241897 cites W1505070929 @default.
- W2753241897 cites W1813230101 @default.
- W2753241897 cites W1879184430 @default.
- W2753241897 cites W1967585926 @default.
- W2753241897 cites W1973724603 @default.
- W2753241897 cites W1975045295 @default.
- W2753241897 cites W1983525499 @default.
- W2753241897 cites W1985084356 @default.
- W2753241897 cites W1991631628 @default.
- W2753241897 cites W1998987657 @default.
- W2753241897 cites W2003139013 @default.
- W2753241897 cites W2005045122 @default.
- W2753241897 cites W2007636933 @default.
- W2753241897 cites W2010524294 @default.
- W2753241897 cites W2013805538 @default.
- W2753241897 cites W2017692041 @default.
- W2753241897 cites W2020349051 @default.
- W2753241897 cites W2020585998 @default.
- W2753241897 cites W2027374513 @default.
- W2753241897 cites W2032062138 @default.
- W2753241897 cites W2034414337 @default.
- W2753241897 cites W2036154524 @default.
- W2753241897 cites W2037689035 @default.
- W2753241897 cites W2040114786 @default.
- W2753241897 cites W2040698471 @default.
- W2753241897 cites W2041600383 @default.
- W2753241897 cites W2045106190 @default.
- W2753241897 cites W2048569323 @default.
- W2753241897 cites W2048719661 @default.
- W2753241897 cites W2049073341 @default.
- W2753241897 cites W2055308573 @default.
- W2753241897 cites W2055456981 @default.
- W2753241897 cites W2062945796 @default.
- W2753241897 cites W2074833985 @default.
- W2753241897 cites W2076598575 @default.
- W2753241897 cites W2080683417 @default.
- W2753241897 cites W2088658333 @default.
- W2753241897 cites W2089097264 @default.
- W2753241897 cites W2089518139 @default.
- W2753241897 cites W2092620381 @default.
- W2753241897 cites W2098303916 @default.
- W2753241897 cites W2104251051 @default.
- W2753241897 cites W2106219242 @default.
- W2753241897 cites W2119582385 @default.
- W2753241897 cites W2122091775 @default.
- W2753241897 cites W2122341467 @default.
- W2753241897 cites W2144437860 @default.
- W2753241897 cites W2144483204 @default.
- W2753241897 cites W2145047941 @default.
- W2753241897 cites W2149959669 @default.
- W2753241897 cites W2152165298 @default.
- W2753241897 cites W2164965901 @default.
- W2753241897 cites W2239083587 @default.
- W2753241897 cites W2318432087 @default.
- W2753241897 doi "https://doi.org/10.1038/s41598-017-12072-5" @default.
- W2753241897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5605738" @default.
- W2753241897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28928373" @default.
- W2753241897 hasPublicationYear "2017" @default.
- W2753241897 type Work @default.
- W2753241897 sameAs 2753241897 @default.
- W2753241897 citedByCount "19" @default.
- W2753241897 countsByYear W27532418972018 @default.
- W2753241897 countsByYear W27532418972019 @default.
- W2753241897 countsByYear W27532418972020 @default.
- W2753241897 countsByYear W27532418972021 @default.
- W2753241897 countsByYear W27532418972022 @default.
- W2753241897 countsByYear W27532418972023 @default.
- W2753241897 crossrefType "journal-article" @default.
- W2753241897 hasAuthorship W2753241897A5026231109 @default.
- W2753241897 hasAuthorship W2753241897A5034529744 @default.
- W2753241897 hasAuthorship W2753241897A5040875680 @default.
- W2753241897 hasAuthorship W2753241897A5042249371 @default.
- W2753241897 hasAuthorship W2753241897A5053139893 @default.
- W2753241897 hasAuthorship W2753241897A5057119874 @default.
- W2753241897 hasAuthorship W2753241897A5061800712 @default.
- W2753241897 hasAuthorship W2753241897A5081370735 @default.
- W2753241897 hasAuthorship W2753241897A5081747194 @default.
- W2753241897 hasBestOaLocation W27532418971 @default.
- W2753241897 hasConcept C104317684 @default.
- W2753241897 hasConcept C142724271 @default.
- W2753241897 hasConcept C143425029 @default.
- W2753241897 hasConcept C1491633281 @default.
- W2753241897 hasConcept C150903083 @default.
- W2753241897 hasConcept C185592680 @default.