Matches in SemOpenAlex for { <https://semopenalex.org/work/W2753245738> ?p ?o ?g. }
- W2753245738 endingPage "3872" @default.
- W2753245738 startingPage "3863" @default.
- W2753245738 abstract "Huntington's disease (HD) is a neurodegenerative disorder induced by aggregation of the pathological form of Huntingtin protein that has expanded polyglutamine (polyQ) repeats. In the Drosophila model, for instance, expression of transgenes with polyQ repeats induces HD-like pathologies, progressively correlating with the increasing lengths of these repeats. Previous studies on both animal models and clinical samples have revealed metabolite imbalances during HD progression. To further explore the physiological processes linked to metabolite imbalances during HD, we have investigated the 1D 1H NMR spectroscopy-based metabolomics profile of Drosophila HD model. Using multivariate analysis (PCA and PLS-DA) of metabolites obtained from methanolic extracts of fly heads displaying retinal deformations due to polyQ overexpression, we show that the metabolite imbalance during HD is likely to affect cell energetics. Six out of the 35 metabolites analyzed, namely, nicotinamide adenine dinucleotide (NAD), lactate, pyruvate, succinate, sarcosine, and acetoin, displayed segregation with progressive severity of HD. Specifically, HD progression was seen to be associated with reduction in NAD and increase in lactate-to-pyruvate ratio. Furthermore, comparative analysis of fly HD metabolome with those of mouse HD model and HD human patients revealed comparable metabolite imbalances, suggesting altered cellular energy homeostasis. These findings thus raise the possibility of therapeutic interventions for HD via modulation of cellular energetics." @default.
- W2753245738 created "2017-09-15" @default.
- W2753245738 creator A5017774594 @default.
- W2753245738 creator A5041209894 @default.
- W2753245738 creator A5044389615 @default.
- W2753245738 creator A5050171498 @default.
- W2753245738 creator A5055028094 @default.
- W2753245738 creator A5060783999 @default.
- W2753245738 date "2017-09-26" @default.
- W2753245738 modified "2023-10-16" @default.
- W2753245738 title "NMR Spectroscopy-based Metabolomics of Drosophila Model of Huntington’s Disease Suggests Altered Cell Energetics" @default.
- W2753245738 cites W1114726613 @default.
- W2753245738 cites W1564629725 @default.
- W2753245738 cites W1643390591 @default.
- W2753245738 cites W1728292606 @default.
- W2753245738 cites W1801065171 @default.
- W2753245738 cites W1964944685 @default.
- W2753245738 cites W1968567748 @default.
- W2753245738 cites W1970396586 @default.
- W2753245738 cites W1972530737 @default.
- W2753245738 cites W1976327004 @default.
- W2753245738 cites W1976817344 @default.
- W2753245738 cites W1979767736 @default.
- W2753245738 cites W1980276147 @default.
- W2753245738 cites W1983543927 @default.
- W2753245738 cites W1987187466 @default.
- W2753245738 cites W1987335374 @default.
- W2753245738 cites W1990625173 @default.
- W2753245738 cites W1994441822 @default.
- W2753245738 cites W1998056500 @default.
- W2753245738 cites W1998074653 @default.
- W2753245738 cites W2000275928 @default.
- W2753245738 cites W2001474776 @default.
- W2753245738 cites W2015555349 @default.
- W2753245738 cites W2016713134 @default.
- W2753245738 cites W2017773340 @default.
- W2753245738 cites W2019954524 @default.
- W2753245738 cites W2020117714 @default.
- W2753245738 cites W2020665084 @default.
- W2753245738 cites W2021145301 @default.
- W2753245738 cites W2029054948 @default.
- W2753245738 cites W2032600136 @default.
- W2753245738 cites W2032817175 @default.
- W2753245738 cites W2033325995 @default.
- W2753245738 cites W2034123113 @default.
- W2753245738 cites W2038120434 @default.
- W2753245738 cites W2038419059 @default.
- W2753245738 cites W2039392338 @default.
- W2753245738 cites W2043078214 @default.
- W2753245738 cites W2044244805 @default.
- W2753245738 cites W2047121554 @default.
- W2753245738 cites W2049376715 @default.
- W2753245738 cites W2051807096 @default.
- W2753245738 cites W2062475597 @default.
- W2753245738 cites W2066324459 @default.
- W2753245738 cites W2067786443 @default.
- W2753245738 cites W2069343505 @default.
- W2753245738 cites W2073988218 @default.
- W2753245738 cites W2075033701 @default.
- W2753245738 cites W2076582387 @default.
- W2753245738 cites W2079515425 @default.
- W2753245738 cites W2082763359 @default.
- W2753245738 cites W2091347056 @default.
- W2753245738 cites W2092979808 @default.
- W2753245738 cites W2100978260 @default.
- W2753245738 cites W2104035332 @default.
- W2753245738 cites W2106902774 @default.
- W2753245738 cites W2107046691 @default.
- W2753245738 cites W2107892061 @default.
- W2753245738 cites W2111856493 @default.
- W2753245738 cites W2114266222 @default.
- W2753245738 cites W2118546680 @default.
- W2753245738 cites W2118649927 @default.
- W2753245738 cites W2118958219 @default.
- W2753245738 cites W2121926054 @default.
- W2753245738 cites W2124911115 @default.
- W2753245738 cites W2128126778 @default.
- W2753245738 cites W2131802378 @default.
- W2753245738 cites W2131866415 @default.
- W2753245738 cites W2133141500 @default.
- W2753245738 cites W2134022293 @default.
- W2753245738 cites W2135124405 @default.
- W2753245738 cites W2139587743 @default.
- W2753245738 cites W2143161560 @default.
- W2753245738 cites W2144126060 @default.
- W2753245738 cites W2145196491 @default.
- W2753245738 cites W2146614932 @default.
- W2753245738 cites W2151245395 @default.
- W2753245738 cites W2158745183 @default.
- W2753245738 cites W2166918488 @default.
- W2753245738 cites W2200373289 @default.
- W2753245738 cites W2223972310 @default.
- W2753245738 cites W2292515622 @default.
- W2753245738 cites W2309982270 @default.
- W2753245738 cites W2319800684 @default.
- W2753245738 cites W2335596686 @default.
- W2753245738 cites W2340041289 @default.
- W2753245738 cites W2410386040 @default.