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- W2753254934 abstract "Objective To investigate the effect of rapamycin on p70s6 kinase (p70S6K) after deprivation of biliary blood supply.Methods Male SD rats were randomly assigned into 4 groups:sham (n =28),sham + rapamycin (n =28),ischemia (n =32) and ischemia + rapamycin (n =32).In ischemia group,complete deprivation of bile duct arterial supply was performed,and in sham group open-close operation was carried out.Daily intake of rapamycin (2 mg/kg) was given in rapamycin-treated groups with the same volume of saline in non-rapamycin-treated groups.Six rats were sacrificed on postoperative day (POD) 1,3 and 7,and the rest sacrificed on POD 14.Fresh liver tissues were obtained.Western blotting was used to detect the content of p70S6K.Kruskal-Wallis H test was used for comparion of multiple independent samples and the following pairwise comparisons were performed by rank transformation and one way ANOVA.Difference between two independent samples was determined by Mann-Whitney U test.Results According to Western blotting,p70S6K was up-regulated in ischemia group,with the peak level of (2.03 ± 0.14),4.43 folds to sham group (P ＜ 0.01).Afgter administration of rapamycin,there was an increase of p70S6K content in biliary ischemic rats,but the peak level of (1.03 ± 0.07) was only 50％ of that in ischemia group (P ＜0.01).Further more,on POD 1,7 and 14,p70S6K content in ischemia + rapamycin group was lower than that in ischemia group (P ＜ 0.005).Conclusion Rapamycin inhibits production of p70S6K,which provides explanation to negative effect of rapamycin on adaptive bile duct proliferation in response to ischemia.Key words: Rapamycin ; Bile duct ischemia; p70S6 kinase" @default.
- W2753254934 created "2017-09-15" @default.
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- W2753254934 date "2013-11-08" @default.
- W2753254934 modified "2023-09-22" @default.
- W2753254934 title "Effect of rapamycin on p70s6 kinase after biliary ischemia in rats" @default.
- W2753254934 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2013.11.009" @default.
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