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- W2753271566 abstract "TKIs are the standard of care for patients with CML-CP, but some patients are resistant to or intolerant of available TKI therapies. Asciminib (ABL001) is a new TKI that targets the myristoyl pocket of BCR-ABL1 and functions as a potent and selective allosteric inhibitor, in contrast to currently available TKIs (eg, imatinib, nilotinib, dasatinib, bosutinib, ponatinib, radotinib) that target the BCR-ABL1 adenosine triphosphate (ATP) binding site. Asciminib has a resistance mutation profile that differs from those of ATP binding–site TKIs (Wylie AA, et al. Nature. 2017;543:733-737) and has shown clinical activity in an ongoing phase 1 study in patients with CML and resistance to/intolerance of prior TKIs (Hughes TP, et al. Blood. 2016;128 [abstract 625])." @default.
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- W2753271566 date "2017-09-01" @default.
- W2753271566 modified "2023-09-23" @default.
- W2753271566 title "Oral Asciminib (ABL001) vs Bosutinib in Patients With Chronic Myeloid Leukemia in Chronic Phase (CML-CP) Who Received ≥ 2 Prior Tyrosine Kinase Inhibitors (TKIs): A Multicenter, Open-Label, Randomized, Phase 3 Study" @default.
- W2753271566 doi "https://doi.org/10.1016/j.clml.2017.07.116" @default.
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