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- W2753291312 abstract "Archaea, bacteria, and eukarya secrete membrane microvesicles (MVs) as a mechanism for intercellular communication. We report the isolation and characterization of MVs from the probiotic strain Lactobacillus casei BL23. MVs were characterized using analytical high performance techniques, DLS, AFM and TEM. Similar to what has been described for other Gram-positive bacteria, MVs were on the nanometric size range (30-50 nm). MVs carried cytoplasmic components such as DNA, RNA and proteins. Using a proteomic approach (LC-MS), we identified a total of 103 proteins; 13 exclusively present in the MVs. The MVs content included cell envelope associated and secretory proteins, heat and cold shock proteins, several metabolic enzymes, proteases, structural components of the ribosome, membrane transporters, cell wall-associated hydrolases and phage related proteins. In particular, we identified proteins described as mediators of Lactobacillus' probiotic effects such as p40, p75 and the product of LCABL_31160, annotated as an adhesion protein. The presence of these proteins suggests a role for the MVs in the bacteria-gastrointestinal cells interface. The expression and further encapsulation of proteins into MVs of GRAS (Generally Recognized as Safe) bacteria could represent a scientific novelty, with applications in food, nutraceuticals and clinical therapies." @default.
- W2753291312 created "2017-09-15" @default.
- W2753291312 creator A5025001078 @default.
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- W2753291312 date "2017-09-20" @default.
- W2753291312 modified "2023-10-16" @default.
- W2753291312 title "Lactobacillus casei BL23 Produces Microvesicles Carrying Proteins That Have Been Associated with Its Probiotic Effect" @default.
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- W2753291312 doi "https://doi.org/10.3389/fmicb.2017.01783" @default.
- W2753291312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5611436" @default.
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- W2753291312 hasPublicationYear "2017" @default.
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