FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2753358648> ?p ?o ?g. }

• W2753358648 endingPage "R308" @default.
• W2753358648 startingPage "R297" @default.
• W2753358648 abstract "Data on cardiovascular disease in primary hyperparathyroidism (PHPT) are controversial; indeed, at present, cardiovascular involvement is not included among the criteria needed for parathyroidectomy. Aim of this narrative review is to analyze the available literature in an effort to better characterize cardiovascular involvement in PHPT. Due to physiological effects of both parathyroid hormone (PTH) and calcium on cardiomyocyte, cardiac conduction system, smooth vascular, endothelial and pancreatic beta cells, a number of data have been published regarding associations between symptomatic and mild PHPT with hypertension, arrhythmias, endothelial dysfunction (an early marker of atherosclerosis), glucose metabolism impairment and metabolic syndrome. However, the results, mainly derived from observational studies, are inconsistent. Furthermore, parathyroidectomy resulted in conflicting outcomes, which may be linked to several potential biases. In particular, differences in the methods utilized for excluding confounding co-existing cardiovascular risk factors together with differences in patient characteristics, with varying degrees of hypercalcemia, may have contributed to these discrepancies. The only meta-analysis carried out in PHPT patients, revealed a positive effect of parathyroidectomy on left ventricular mass index (a predictor of cardiovascular mortality) and more importantly, that the highest pre-operative PTH levels were associated with the greatest improvements. In normocalcemic PHPT, it has been demonstrated that cardiovascular risk factors are almost similar compared to hypercalcemic PHPT, thus strengthening the role of PTH in the cardiovascular involvement. Long-term longitudinal randomized trials are needed to determine the impact of parathyroidectomy on cardiovascular diseases and mortality in PHPT." @default.
• W2753358648 created "2017-09-15" @default.
• W2753358648 creator A5015966662 @default.
• W2753358648 creator A5023342874 @default.
• W2753358648 creator A5052786698 @default.
• W2753358648 creator A5054016902 @default.
• W2753358648 creator A5054326025 @default.
• W2753358648 creator A5077696941 @default.
• W2753358648 date "2017-12-01" @default.
• W2753358648 modified "2023-10-12" @default.
• W2753358648 title "Cardiovascular manifestations of primary hyperparathyroidism: a narrative review" @default.
• W2753358648 cites W1512782010 @default.
• W2753358648 cites W1788326235 @default.
• W2753358648 cites W1956046199 @default.
• W2753358648 cites W1965773910 @default.
• W2753358648 cites W1970938120 @default.
• W2753358648 cites W1971863892 @default.
• W2753358648 cites W1973764716 @default.
• W2753358648 cites W1975807122 @default.
• W2753358648 cites W1976524871 @default.
• W2753358648 cites W1978407488 @default.
• W2753358648 cites W1978582472 @default.
• W2753358648 cites W1982052351 @default.
• W2753358648 cites W1987110861 @default.
• W2753358648 cites W1989746218 @default.
• W2753358648 cites W1996617445 @default.
• W2753358648 cites W1998937022 @default.
• W2753358648 cites W2005111245 @default.
• W2753358648 cites W2006632162 @default.
• W2753358648 cites W2011464926 @default.
• W2753358648 cites W2019537096 @default.
• W2753358648 cites W2023861169 @default.
• W2753358648 cites W2025222301 @default.
• W2753358648 cites W2026526801 @default.
• W2753358648 cites W2029200191 @default.
• W2753358648 cites W2029566581 @default.
• W2753358648 cites W2031532313 @default.
• W2753358648 cites W2031595428 @default.
• W2753358648 cites W2037770102 @default.
• W2753358648 cites W2041937211 @default.
• W2753358648 cites W2044897750 @default.
• W2753358648 cites W2045492790 @default.
• W2753358648 cites W2048391763 @default.
• W2753358648 cites W2050840921 @default.
• W2753358648 cites W2051822015 @default.
• W2753358648 cites W2056702047 @default.
• W2753358648 cites W2057135857 @default.
• W2753358648 cites W2062309517 @default.
• W2753358648 cites W2064587699 @default.
• W2753358648 cites W2066055420 @default.
• W2753358648 cites W2067075853 @default.
• W2753358648 cites W2068248907 @default.
• W2753358648 cites W2068285293 @default.
• W2753358648 cites W2069642422 @default.
• W2753358648 cites W2074996493 @default.
• W2753358648 cites W2075996870 @default.
• W2753358648 cites W2082237792 @default.
• W2753358648 cites W2083298079 @default.
• W2753358648 cites W2085874802 @default.
• W2753358648 cites W2087941798 @default.
• W2753358648 cites W2088210068 @default.
• W2753358648 cites W2088687280 @default.
• W2753358648 cites W2090412719 @default.
• W2753358648 cites W2092161654 @default.
• W2753358648 cites W2093318399 @default.
• W2753358648 cites W2094198540 @default.
• W2753358648 cites W2096130027 @default.
• W2753358648 cites W2096681358 @default.
• W2753358648 cites W2099029435 @default.
• W2753358648 cites W2099487746 @default.
• W2753358648 cites W2101489363 @default.
• W2753358648 cites W2103155778 @default.
• W2753358648 cites W2103714496 @default.
• W2753358648 cites W2104321926 @default.
• W2753358648 cites W2104954752 @default.
• W2753358648 cites W2105723615 @default.
• W2753358648 cites W2108185128 @default.
• W2753358648 cites W2108542263 @default.
• W2753358648 cites W2109509624 @default.
• W2753358648 cites W2109629573 @default.
• W2753358648 cites W2111131646 @default.
• W2753358648 cites W2111831785 @default.
• W2753358648 cites W2125248945 @default.
• W2753358648 cites W2128786663 @default.
• W2753358648 cites W2129140008 @default.
• W2753358648 cites W2134445887 @default.
• W2753358648 cites W2134498532 @default.
• W2753358648 cites W2134638476 @default.
• W2753358648 cites W2140938262 @default.
• W2753358648 cites W2141657676 @default.
• W2753358648 cites W2143159746 @default.
• W2753358648 cites W2145655666 @default.
• W2753358648 cites W2147256340 @default.
• W2753358648 cites W2148853530 @default.
• W2753358648 cites W2149309894 @default.
• W2753358648 cites W2150182249 @default.
• W2753358648 cites W2153258977 @default.
• W2753358648 cites W2161698416 @default.

• next