Matches in SemOpenAlex for { <https://semopenalex.org/work/W2753371539> ?p ?o ?g. }
- W2753371539 endingPage "487" @default.
- W2753371539 startingPage "461" @default.
- W2753371539 abstract "Colorectal cancers (CRCs) are thought to arise through accumulation of genetic and epigenetic alterations. CRC genomes exhibit dual-faceted DNA methylation abnormality, global hypomethylation with CpG island hypermethylation, and CRCs are classified into two groups based on whether their genomes exhibit microsatellite instability (MSI) or chromosomal instability (CIN). In addition, a subset of CRCs is characterized by concurrent hypermethylation of multiple CpG islands, known as the CpG island methylator phenotype (CIMP). Genomic instability and epigenetic alterations are tightly linked, and CRCs with MSI largely overlap CIMP-positive tumors, while CIN is associated with global DNA hypomethylation. Dysregulation of histone methylation and altered expression of histone modifying enzymes are also commonly observed in CRC, indicating their critical roles in CRC development. Evidence now suggests that DNA and histone methylation could potentially serve as biomarkers useful for CRC diagnosis, risk assessment and prediction of therapeutic effects and prognosis. Although many studies examining clinical applications are still at an early phase, it is anticipated that further investigation will lead to improved prevention and management of CRC." @default.
- W2753371539 created "2017-09-15" @default.
- W2753371539 creator A5002391399 @default.
- W2753371539 creator A5049246136 @default.
- W2753371539 creator A5064856279 @default.
- W2753371539 creator A5088527994 @default.
- W2753371539 date "2017-01-01" @default.
- W2753371539 modified "2023-09-24" @default.
- W2753371539 title "DNA and Histone Methylation in Colon Cancer" @default.
- W2753371539 cites W1522855936 @default.
- W2753371539 cites W1553974447 @default.
- W2753371539 cites W1579447084 @default.
- W2753371539 cites W1639623904 @default.
- W2753371539 cites W1648301895 @default.
- W2753371539 cites W1757407923 @default.
- W2753371539 cites W1934094702 @default.
- W2753371539 cites W1939927669 @default.
- W2753371539 cites W1965997942 @default.
- W2753371539 cites W1969670934 @default.
- W2753371539 cites W1971937022 @default.
- W2753371539 cites W1972168013 @default.
- W2753371539 cites W1972254989 @default.
- W2753371539 cites W1974439810 @default.
- W2753371539 cites W1975120352 @default.
- W2753371539 cites W1975224807 @default.
- W2753371539 cites W1975860179 @default.
- W2753371539 cites W1980009033 @default.
- W2753371539 cites W1980022114 @default.
- W2753371539 cites W1986746348 @default.
- W2753371539 cites W1987648433 @default.
- W2753371539 cites W1988756388 @default.
- W2753371539 cites W1990016987 @default.
- W2753371539 cites W1990557296 @default.
- W2753371539 cites W1990964644 @default.
- W2753371539 cites W1992707318 @default.
- W2753371539 cites W1994536220 @default.
- W2753371539 cites W1994951109 @default.
- W2753371539 cites W1995070143 @default.
- W2753371539 cites W1999707279 @default.
- W2753371539 cites W2001374534 @default.
- W2753371539 cites W2002826921 @default.
- W2753371539 cites W2003056152 @default.
- W2753371539 cites W2005458309 @default.
- W2753371539 cites W2006239354 @default.
- W2753371539 cites W2008745743 @default.
- W2753371539 cites W2008945738 @default.
- W2753371539 cites W2010868528 @default.
- W2753371539 cites W2011831296 @default.
- W2753371539 cites W2012697899 @default.
- W2753371539 cites W2013521944 @default.
- W2753371539 cites W2013682516 @default.
- W2753371539 cites W2015754967 @default.
- W2753371539 cites W2019527553 @default.
- W2753371539 cites W2020860656 @default.
- W2753371539 cites W2021164904 @default.
- W2753371539 cites W2021362203 @default.
- W2753371539 cites W2023397076 @default.
- W2753371539 cites W2023473560 @default.
- W2753371539 cites W2027312402 @default.
- W2753371539 cites W2029276420 @default.
- W2753371539 cites W2029462077 @default.
- W2753371539 cites W2029843689 @default.
- W2753371539 cites W2030134289 @default.
- W2753371539 cites W2030406772 @default.
- W2753371539 cites W2031698214 @default.
- W2753371539 cites W2033126020 @default.
- W2753371539 cites W2036885749 @default.
- W2753371539 cites W2038412530 @default.
- W2753371539 cites W2040426919 @default.
- W2753371539 cites W2041263849 @default.
- W2753371539 cites W2041686632 @default.
- W2753371539 cites W2042087070 @default.
- W2753371539 cites W2043363016 @default.
- W2753371539 cites W2043905028 @default.
- W2753371539 cites W2044204537 @default.
- W2753371539 cites W2045933328 @default.
- W2753371539 cites W2048280970 @default.
- W2753371539 cites W2048355047 @default.
- W2753371539 cites W2053421436 @default.
- W2753371539 cites W2054818135 @default.
- W2753371539 cites W2055685287 @default.
- W2753371539 cites W2056918422 @default.
- W2753371539 cites W2062583086 @default.
- W2753371539 cites W2062586342 @default.
- W2753371539 cites W2064228418 @default.
- W2753371539 cites W2064854706 @default.
- W2753371539 cites W2065725486 @default.
- W2753371539 cites W2067929611 @default.
- W2753371539 cites W2068191747 @default.
- W2753371539 cites W2073587729 @default.
- W2753371539 cites W2074279306 @default.
- W2753371539 cites W2078158452 @default.
- W2753371539 cites W2078972833 @default.
- W2753371539 cites W2079322691 @default.
- W2753371539 cites W2082671589 @default.
- W2753371539 cites W2084469088 @default.
- W2753371539 cites W2088987931 @default.
- W2753371539 cites W2090062366 @default.