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- W2753378858 abstract "Lantibiotics are (methyl)-lanthionine-containing antimicrobial peptides produced by several Gram-positive bacteria. Some human pathogenic bacteria express specific resistance proteins that counteract this antimicrobial activity of lantibiotics. In Streptococcus agalactiae COH1 resistance against the well-known lantibiotic nisin is conferred by, the nisin resistance protein (NSR), a two-component system (NsrRK) and a BceAB-type ABC transporter (NsrFP). The present study focuses on elucidating the function of NsrFP via its heterologous expression in Lactoccocus lactis. NsrFP is able to convert a 16-fold resistance against wild type nisin as determined by growth inhibition experiments and functions as a lantibiotic exporter. Several C-terminal nisin mutants indicated that NsrFP recognizes the N-terminal region of nisin. The N-terminus harbours two (methyl)-lanthionine rings, which are conserved in other lantibiotics." @default.
- W2753378858 created "2017-09-15" @default.
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- W2753378858 date "2017-08-29" @default.
- W2753378858 modified "2023-09-27" @default.
- W2753378858 title "The N-terminal Region of Nisin Is Important for the BceAB-Type ABC Transporter NsrFP from Streptococcus agalactiae COH1" @default.
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- W2753378858 doi "https://doi.org/10.3389/fmicb.2017.01643" @default.
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