SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2753443762> ?p ?o ?g. }

Showing items 1 to 100 of ±150 with 100 items per page.

W2753443762 endingPage "37" @default.
W2753443762 startingPage "25" @default.
W2753443762 abstract "A growing body of evidence suggests that stress triggers a variety of pathophysiological responses. Recent studies show that stress produces enduring effects on structure and function of hippocampus, which is one of the most important structures involved in epilepsy. In the present study, we determined the effect of repeated restraint stress exposure on the susceptibility of pentylenetetrazole (PTZ)-induced seizures and the possible mechanisms involved using a rodent model. Our results show that mice subjected to repeated restraint stress exhibited shorter latency to PTZ-induced tonic-clonic seizures and higher seizure severity, suggesting chronic restraint stress increases seizure susceptibility. Following repeated restraint stress, we observed an increased level of endoplasmic reticulum (ER) stress as well as oxidative stress in the hippocampus. Moreover, our results show that chronic restraint stress exposure causes neuron loss in the hippocampus. Inhibition of ER stress with chemical chaperone, tauroursodeoxycholic acid (TUDCA), however, protects against chronic restraint stress-induced neuron loss, suggesting repeated restraint stress-induced neuronal degeneration is dependent on ER stress activation. On the other hand, inhibition of ER stress with TUDCA suppresses restraint stress-induced seizure susceptibility. Taken together, these results indicate that repeated restraint stress increases seizure susceptibility by activation of hippocampal ER stress and ER stress mediated oxidative stress and neurodegeneration. Thus, attenuating ER stress may serve as a potential therapeutic strategy targeted to block stress-induced seizure activities." @default.
W2753443762 created "2017-09-15" @default.
W2753443762 creator A5003392178 @default.
W2753443762 creator A5011257788 @default.
W2753443762 creator A5011785535 @default.
W2753443762 creator A5015678905 @default.
W2753443762 creator A5063511354 @default.
W2753443762 creator A5087353389 @default.
W2753443762 date "2017-11-01" @default.
W2753443762 modified "2023-09-24" @default.
W2753443762 title "Repeated restraint stress increases seizure susceptibility by activation of hippocampal endoplasmic reticulum stress" @default.
W2753443762 cites W1444780264 @default.
W2753443762 cites W1753989155 @default.
W2753443762 cites W1880862139 @default.
W2753443762 cites W1963745928 @default.
W2753443762 cites W1972008702 @default.
W2753443762 cites W1973357433 @default.
W2753443762 cites W1976161806 @default.
W2753443762 cites W1977603207 @default.
W2753443762 cites W1983602602 @default.
W2753443762 cites W1984332363 @default.
W2753443762 cites W1986977415 @default.
W2753443762 cites W1989640932 @default.
W2753443762 cites W1994404120 @default.
W2753443762 cites W1994613811 @default.
W2753443762 cites W1998566684 @default.
W2753443762 cites W2000196009 @default.
W2753443762 cites W2001167919 @default.
W2753443762 cites W2001399725 @default.
W2753443762 cites W2001566658 @default.
W2753443762 cites W2003115198 @default.
W2753443762 cites W2008387107 @default.
W2753443762 cites W2010692367 @default.
W2753443762 cites W2012985830 @default.
W2753443762 cites W2018395823 @default.
W2753443762 cites W2018630482 @default.
W2753443762 cites W2021385892 @default.
W2753443762 cites W2023343492 @default.
W2753443762 cites W2023691970 @default.
W2753443762 cites W2029672076 @default.
W2753443762 cites W2029899890 @default.
W2753443762 cites W2038920951 @default.
W2753443762 cites W2040848606 @default.
W2753443762 cites W2043387126 @default.
W2753443762 cites W2044220354 @default.
W2753443762 cites W2048456744 @default.
W2753443762 cites W2057289954 @default.
W2753443762 cites W2058382965 @default.
W2753443762 cites W2059227777 @default.
W2753443762 cites W2059552796 @default.
W2753443762 cites W2062865967 @default.
W2753443762 cites W2070308471 @default.
W2753443762 cites W2076979334 @default.
W2753443762 cites W2088835723 @default.
W2753443762 cites W2092106059 @default.
W2753443762 cites W2100417958 @default.
W2753443762 cites W2103506573 @default.
W2753443762 cites W2124457325 @default.
W2753443762 cites W2135890562 @default.
W2753443762 cites W2136403062 @default.
W2753443762 cites W2136609251 @default.
W2753443762 cites W2142861949 @default.
W2753443762 cites W2144920399 @default.
W2753443762 cites W2155533976 @default.
W2753443762 cites W2165064047 @default.
W2753443762 cites W2167500696 @default.
W2753443762 cites W2169612876 @default.
W2753443762 cites W2296699107 @default.
W2753443762 cites W2300528976 @default.
W2753443762 cites W2334695248 @default.
W2753443762 cites W2338803661 @default.
W2753443762 cites W2344203330 @default.
W2753443762 cites W2403661886 @default.
W2753443762 doi "https://doi.org/10.1016/j.neuint.2017.09.002" @default.
W2753443762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28887093" @default.
W2753443762 hasPublicationYear "2017" @default.
W2753443762 type Work @default.
W2753443762 sameAs 2753443762 @default.
W2753443762 citedByCount "21" @default.
W2753443762 countsByYear W27534437622019 @default.
W2753443762 countsByYear W27534437622020 @default.
W2753443762 countsByYear W27534437622021 @default.
W2753443762 countsByYear W27534437622022 @default.
W2753443762 countsByYear W27534437622023 @default.
W2753443762 crossrefType "journal-article" @default.
W2753443762 hasAuthorship W2753443762A5003392178 @default.
W2753443762 hasAuthorship W2753443762A5011257788 @default.
W2753443762 hasAuthorship W2753443762A5011785535 @default.
W2753443762 hasAuthorship W2753443762A5015678905 @default.
W2753443762 hasAuthorship W2753443762A5063511354 @default.
W2753443762 hasAuthorship W2753443762A5087353389 @default.
W2753443762 hasConcept C126322002 @default.
W2753443762 hasConcept C134018914 @default.
W2753443762 hasConcept C139447449 @default.
W2753443762 hasConcept C148762608 @default.
W2753443762 hasConcept C158617107 @default.
W2753443762 hasConcept C169760540 @default.
W2753443762 hasConcept C185592680 @default.