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• W2753467244 abstract "Purpose: This is a review of emerging targeted, systemic therapies for atopic dermatitis (AD). The information presented aims to provide dermatologists with updated therapeutic options, stimulate academic interest, and spark future research.Material and methods: Extensive search of ClinicalTrials.gov, the National Eczema Association, and PubMed was performed for clinical trials examining the effect of emerging targeted, systemic therapies in patients with AD. Results were included if they demonstrated efficacy in reversing AD symptoms. Studies that did not demonstrate clinical benefit were excluded.Results: A number of emerging systemic agents targeting specific mediators involved in the pathogenesis of AD were found. These targets include IL-4, IL-13, IgE, B-cells, IL-5, IL-31, JAK-STAT, SYK, IL-6, PDE-4, IL-12, IL-17, IL-23, IL-22, H4R, NKR1, κOR, TSLP, PPAR-γ, and DGLA. Treatment of AD patients with these therapies has, in many cases, led to statistically significant improvements in clinical severity scores and patient-reported outcomes.Conclusions: While multiple agents have demonstrated efficacy, only dupilumab is currently approved for adults with AD. Large-scale, randomized, placebo-controlled, double-blind trials, especially in children, are needed. As we enter the dawn of targeted therapy for AD, a comprehensive clinical trial registry is needed to facilitate data pooling and comparison among international registries." @default.
• W2753467244 created "2017-09-15" @default.
• W2753467244 creator A5002888235 @default.
• W2753467244 creator A5018135376 @default.
• W2753467244 creator A5041588654 @default.
• W2753467244 creator A5068372166 @default.
• W2753467244 date "2017-09-19" @default.
• W2753467244 modified "2023-09-26" @default.
• W2753467244 title "New and emerging targeted systemic therapies: a new era for atopic dermatitis" @default.
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• W2753467244 doi "https://doi.org/10.1080/09546634.2017.1373736" @default.
• W2753467244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28853956" @default.
• W2753467244 hasPublicationYear "2017" @default.
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