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- W2753510634 abstract "The intestine may be subjected to simple obstruction, in which only the lumen is obstructed, strangulating obstruction, in which both the lumen and vasculature are obstructed, or infarction, in which only the vasculature is obstructed. Each of these may injure intestinal tissues, particularly with interruption of blood flow and subsequent ischemic injury. This can also occur in simple obstruction as the luminal pressure causes collapse of the vasculature within the intestinal wall. Once reperfused, ischemic-injured mucosa may undergo reperfusion injury, depending on the circumstances. This relates to the level of reactive oxygen metabolite generation and infiltration of neutrophils. More recently, repair of the mucosa has been studied in depth, including villus contraction (in the small intestine), epithelial restitution, tight junction closure, and mucosal proliferation. Other layers of the intestine are also injured, particularly the serosa, which can lead to inflammation and development of adhesions." @default.
- W2753510634 created "2017-09-15" @default.
- W2753510634 creator A5012790296 @default.
- W2753510634 date "2017-09-01" @default.
- W2753510634 modified "2023-09-23" @default.
- W2753510634 title "Pathophysiology of Gastrointestinal Obstruction and Strangulation" @default.
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- W2753510634 doi "https://doi.org/10.1002/9781119063254.ch11" @default.
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