FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2753529130> ?p ?o ?g. }

• W2753529130 abstract "Aim Studies on gestational diabetes (GDM) have highlighted the induction of genes involved in the immune response, particularly those associated with inflammation. HLA-C, HLA-E and HLA-G are the only HLA genes expressed on trophoblast cells, playing an important role in the modulation of the maternal immune response against the fetus. Considering that: (i) there is a similar transcriptional profile between GDM and the autoimmune type 1 diabetes mellitus; and (ii) some allelic combinations between KIR and HLA genes, mainly HLA-C, are strongly associated with pre-eclampsia and recurrent miscarriage, we investigated the possible role of HLA-C, -E and -G variability in GDM. Methods We evaluated 102 GDM and 150 non-GDM women to detect HLA-C, -E and -G polymorphisms and haplotypes considering the entire gene segment, including the promoter, coding sequence and 3’untranslated region (3’UTR), by using next generation sequencing and a local bioinformatics strategy to get reliable genotypes and haplotypes. Results We observed 14 allelic groups when the HLA-C gene was evaluated, and two of them (HLA-C∗05, mainly represented by the C∗05:01:01, and HLA-C∗08, mainly represented by the allele C∗08:02:01) were associated with protection against GDM (P = 0.0376, OR = 0.3450 and P = 0.0184, OR = 0.2894 respectively). An HLA-C promoter region here named P09 and a 3’UTR here named U09 are strongly associated with protection against GDM (P = 0.0376 OR = 0.3450). These regulatory haplotypes are in fact shared by all C∗05 and C∗08 alleles here detected, suggesting that the protective feature against GDM could be associated with some trait of these specific regulatory regions or associated with the C∗05 or C∗08 allele groups or both. The HLA-E∗01:03:05 allele, originally described in a Brazilian population, was observed only in controls, indicating a protection role for GDM (P = 0.033 and OR = 0.1343). No associations were observed for the HLA-G, considering allele, coding region, promoter, 3’UTR or extended haplotype. Conclusions Only HLA-C and HLA-E were associated with GDM, by mechanisms yet to be understood and explored. The study of other HLA genes, as well as the transcription profiles observed in GDM patients, may increase the understanding of the role of these genes in the pathogenesis of GDM." @default.
• W2753529130 created "2017-09-15" @default.
• W2753529130 creator A5000389584 @default.
• W2753529130 creator A5008722736 @default.
• W2753529130 creator A5015874789 @default.
• W2753529130 creator A5019468704 @default.
• W2753529130 creator A5034726506 @default.
• W2753529130 creator A5039463155 @default.
• W2753529130 creator A5061587246 @default.
• W2753529130 creator A5089582443 @default.
• W2753529130 date "2017-09-01" @default.
• W2753529130 modified "2023-10-18" @default.
• W2753529130 title "P014 HLA-C, HLA-E and HLA-G regulatory and coding region polymorphisms in patients exhibiting gestational diabetes mellitus" @default.
• W2753529130 doi "https://doi.org/10.1016/j.humimm.2017.06.074" @default.
• W2753529130 hasPublicationYear "2017" @default.
• W2753529130 type Work @default.
• W2753529130 sameAs 2753529130 @default.
• W2753529130 citedByCount "1" @default.
• W2753529130 countsByYear W27535291302020 @default.
• W2753529130 crossrefType "journal-article" @default.
• W2753529130 hasAuthorship W2753529130A5000389584 @default.
• W2753529130 hasAuthorship W2753529130A5008722736 @default.
• W2753529130 hasAuthorship W2753529130A5015874789 @default.
• W2753529130 hasAuthorship W2753529130A5019468704 @default.
• W2753529130 hasAuthorship W2753529130A5034726506 @default.
• W2753529130 hasAuthorship W2753529130A5039463155 @default.
• W2753529130 hasAuthorship W2753529130A5061587246 @default.
• W2753529130 hasAuthorship W2753529130A5089582443 @default.
• W2753529130 hasBestOaLocation W27535291302 @default.
• W2753529130 hasConcept C104317684 @default.
• W2753529130 hasConcept C135763542 @default.
• W2753529130 hasConcept C147483822 @default.
• W2753529130 hasConcept C180754005 @default.
• W2753529130 hasConcept C188280979 @default.
• W2753529130 hasConcept C197754878 @default.
• W2753529130 hasConcept C203014093 @default.
• W2753529130 hasConcept C2779234561 @default.
• W2753529130 hasConcept C2779434492 @default.
• W2753529130 hasConcept C2780027760 @default.
• W2753529130 hasConcept C46973012 @default.
• W2753529130 hasConcept C54355233 @default.
• W2753529130 hasConcept C86803240 @default.
• W2753529130 hasConcept C8891405 @default.
• W2753529130 hasConceptScore W2753529130C104317684 @default.
• W2753529130 hasConceptScore W2753529130C135763542 @default.
• W2753529130 hasConceptScore W2753529130C147483822 @default.
• W2753529130 hasConceptScore W2753529130C180754005 @default.
• W2753529130 hasConceptScore W2753529130C188280979 @default.
• W2753529130 hasConceptScore W2753529130C197754878 @default.
• W2753529130 hasConceptScore W2753529130C203014093 @default.
• W2753529130 hasConceptScore W2753529130C2779234561 @default.
• W2753529130 hasConceptScore W2753529130C2779434492 @default.
• W2753529130 hasConceptScore W2753529130C2780027760 @default.
• W2753529130 hasConceptScore W2753529130C46973012 @default.
• W2753529130 hasConceptScore W2753529130C54355233 @default.
• W2753529130 hasConceptScore W2753529130C86803240 @default.
• W2753529130 hasConceptScore W2753529130C8891405 @default.
• W2753529130 hasLocation W27535291301 @default.
• W2753529130 hasLocation W27535291302 @default.
• W2753529130 hasOpenAccess W2753529130 @default.
• W2753529130 hasPrimaryLocation W27535291301 @default.
• W2753529130 hasRelatedWork W1916818105 @default.
• W2753529130 hasRelatedWork W1999718325 @default.
• W2753529130 hasRelatedWork W2005356215 @default.
• W2753529130 hasRelatedWork W2006256967 @default.
• W2753529130 hasRelatedWork W2012256031 @default.
• W2753529130 hasRelatedWork W2041572543 @default.
• W2753529130 hasRelatedWork W2065817141 @default.
• W2753529130 hasRelatedWork W2095701822 @default.
• W2753529130 hasRelatedWork W2120495261 @default.
• W2753529130 hasRelatedWork W2135139061 @default.
• W2753529130 hasRelatedWork W2150277814 @default.
• W2753529130 hasRelatedWork W2178798753 @default.
• W2753529130 hasRelatedWork W2224703438 @default.
• W2753529130 hasRelatedWork W2342445827 @default.
• W2753529130 hasRelatedWork W2570978241 @default.
• W2753529130 hasRelatedWork W2804067486 @default.
• W2753529130 hasRelatedWork W2887589313 @default.
• W2753529130 hasRelatedWork W2935729650 @default.
• W2753529130 hasRelatedWork W3001530146 @default.
• W2753529130 hasRelatedWork W2184457876 @default.
• W2753529130 isParatext "false" @default.
• W2753529130 isRetracted "false" @default.
• W2753529130 magId "2753529130" @default.
• W2753529130 workType "article" @default.