Matches in SemOpenAlex for { <https://semopenalex.org/work/W2753548604> ?p ?o ?g. }
- W2753548604 endingPage "98" @default.
- W2753548604 startingPage "86" @default.
- W2753548604 abstract "Tubulin-targeting compounds have a broad anticancer spectrum and are an important class of chemotherapeutic agents. Due to the importance of 3-bromo-3,5-dimethoxyphenyl scaffold in the anticancer activity of microtubule inhibitors such as crolibulin (EPC2407), we introduced this functionality into the indole-derived chalcones. Thus, we describe here the synthesis and biological evaluation of new indole-based chalconoids as tubulin-targeting antiproliferative agents. The best result was obtained by compound 9b against A549 cell with IC50 of 4.3µg/mL, being more potent than the reference drug etoposide. Further biological evaluations revealed that compound 9b can inhibit tubulin polymerization and decrease the mitochondrial thiol content, resulting the induction of apoptosis in cancer cells. Docking studies with tubulin indicated that compound 9b could bind to the colchicine binding site." @default.
- W2753548604 created "2017-09-15" @default.
- W2753548604 creator A5028582868 @default.
- W2753548604 creator A5037384320 @default.
- W2753548604 creator A5038498060 @default.
- W2753548604 creator A5041924332 @default.
- W2753548604 creator A5071038777 @default.
- W2753548604 creator A5074105554 @default.
- W2753548604 date "2017-12-01" @default.
- W2753548604 modified "2023-10-03" @default.
- W2753548604 title "New indole-based chalconoids as tubulin-targeting antiproliferative agents" @default.
- W2753548604 cites W1031578623 @default.
- W2753548604 cites W1509047871 @default.
- W2753548604 cites W1524076404 @default.
- W2753548604 cites W1873243905 @default.
- W2753548604 cites W1964365641 @default.
- W2753548604 cites W1965774693 @default.
- W2753548604 cites W1975376070 @default.
- W2753548604 cites W1976394660 @default.
- W2753548604 cites W1978611453 @default.
- W2753548604 cites W1981737096 @default.
- W2753548604 cites W1981806030 @default.
- W2753548604 cites W1990116973 @default.
- W2753548604 cites W1994297035 @default.
- W2753548604 cites W2010233441 @default.
- W2753548604 cites W2012510781 @default.
- W2753548604 cites W2016341726 @default.
- W2753548604 cites W2017733581 @default.
- W2753548604 cites W2018439225 @default.
- W2753548604 cites W2023893511 @default.
- W2753548604 cites W2027181731 @default.
- W2753548604 cites W2029667189 @default.
- W2753548604 cites W2031823050 @default.
- W2753548604 cites W2031879715 @default.
- W2753548604 cites W2033412016 @default.
- W2753548604 cites W2037237138 @default.
- W2753548604 cites W2039799458 @default.
- W2753548604 cites W2048312098 @default.
- W2753548604 cites W2048883883 @default.
- W2753548604 cites W2056426810 @default.
- W2753548604 cites W2063576996 @default.
- W2753548604 cites W2064571598 @default.
- W2753548604 cites W2064808863 @default.
- W2753548604 cites W2069280729 @default.
- W2753548604 cites W2070835985 @default.
- W2753548604 cites W2085936673 @default.
- W2753548604 cites W2093283271 @default.
- W2753548604 cites W2122996764 @default.
- W2753548604 cites W2144941444 @default.
- W2753548604 cites W2151325092 @default.
- W2753548604 cites W2164195423 @default.
- W2753548604 cites W2165629556 @default.
- W2753548604 cites W2170822039 @default.
- W2753548604 cites W2183025438 @default.
- W2753548604 cites W2321088547 @default.
- W2753548604 cites W2341769195 @default.
- W2753548604 cites W2346984247 @default.
- W2753548604 cites W2414404407 @default.
- W2753548604 cites W2521235664 @default.
- W2753548604 cites W2551633713 @default.
- W2753548604 cites W2954505831 @default.
- W2753548604 cites W4293247451 @default.
- W2753548604 doi "https://doi.org/10.1016/j.bioorg.2017.09.005" @default.
- W2753548604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28922629" @default.
- W2753548604 hasPublicationYear "2017" @default.
- W2753548604 type Work @default.
- W2753548604 sameAs 2753548604 @default.
- W2753548604 citedByCount "47" @default.
- W2753548604 countsByYear W27535486042018 @default.
- W2753548604 countsByYear W27535486042019 @default.
- W2753548604 countsByYear W27535486042020 @default.
- W2753548604 countsByYear W27535486042021 @default.
- W2753548604 countsByYear W27535486042022 @default.
- W2753548604 countsByYear W27535486042023 @default.
- W2753548604 crossrefType "journal-article" @default.
- W2753548604 hasAuthorship W2753548604A5028582868 @default.
- W2753548604 hasAuthorship W2753548604A5037384320 @default.
- W2753548604 hasAuthorship W2753548604A5038498060 @default.
- W2753548604 hasAuthorship W2753548604A5041924332 @default.
- W2753548604 hasAuthorship W2753548604A5071038777 @default.
- W2753548604 hasAuthorship W2753548604A5074105554 @default.
- W2753548604 hasConcept C159110408 @default.
- W2753548604 hasConcept C185592680 @default.
- W2753548604 hasConcept C192527728 @default.
- W2753548604 hasConcept C20418707 @default.
- W2753548604 hasConcept C2776636253 @default.
- W2753548604 hasConcept C2776694085 @default.
- W2753548604 hasConcept C2778119113 @default.
- W2753548604 hasConcept C2778143360 @default.
- W2753548604 hasConcept C41685203 @default.
- W2753548604 hasConcept C54355233 @default.
- W2753548604 hasConcept C55493867 @default.
- W2753548604 hasConcept C71240020 @default.
- W2753548604 hasConcept C71924100 @default.
- W2753548604 hasConcept C84425145 @default.
- W2753548604 hasConcept C86803240 @default.
- W2753548604 hasConcept C95444343 @default.
- W2753548604 hasConceptScore W2753548604C159110408 @default.