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• W2753639045 endingPage "e0005882" @default.
• W2753639045 startingPage "e0005882" @default.
• W2753639045 abstract "Background The complexity of the eukaryotic parasite Trypanosoma (T.) cruzi manifests in its highly dynamic genome, multi-host life cycle, progressive morphologies and immune-evasion mechanisms. Accurate determination of infection or Chagas’ disease activity and prognosis continues to challenge researchers. We hypothesized that a diagnostic platform with higher ligand complexity than previously employed may hold value. Methodology We applied the ImmunoSignature Technology (IST) for the detection of T. cruzi-specific antibodies among healthy blood donors. IST is based on capturing the information in an individual’s antibody repertoire by exposing their peripheral blood to a library of >100,000 position-addressable, chemically-diverse peptides. Principal findings Initially, samples from two Chagas cohorts declared positive or negative by bank testing were studied. With the first cohort, library-peptides displaying differential binding signals between T. cruzi sero-states were used to train an algorithm. A classifier was fixed and tested against the training-independent second cohort to determine assay performance. Next, samples from a mixed cohort of donors declared positive for Chagas, hepatitis B, hepatitis C or West Nile virus were assayed on the same library. Signals were used to train a single algorithm that distinguished all four disease states. As a binary test, the accuracy of predicting T. cruzi seropositivity by IST was similar, perhaps modestly reduced, relative to conventional ELISAs. However, the results indicate that information beyond determination of seropositivity may have been captured. These include the identification of cohort subclasses, the simultaneous detection and discerning of other diseases, and the discovery of putative new antigens. Conclusions & significance The central outcome of this study established IST as a reliable approach for specific determination of T. cruzi seropositivity versus disease-free individuals or those with other diseases. Its potential contribution for monitoring and controlling Chagas lies in IST’s delivery of higher resolution immune-state readouts than obtained with currently-used technologies. Despite the complexity of the ligand presentation and large quantitative readouts, performing an IST test is simple, scalable and reproducible." @default.
• W2753639045 created "2017-09-15" @default.
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• W2753639045 date "2017-09-05" @default.
• W2753639045 modified "2023-09-27" @default.
• W2753639045 title "An ImmunoSignature test distinguishes Trypanosoma cruzi, hepatitis B, hepatitis C and West Nile virus seropositivity among asymptomatic blood donors" @default.
• W2753639045 cites W1488321241 @default.
• W2753639045 cites W1569904907 @default.
• W2753639045 cites W1574069111 @default.
• W2753639045 cites W1659313070 @default.
• W2753639045 cites W1710235422 @default.
• W2753639045 cites W1754445010 @default.
• W2753639045 cites W1863368805 @default.
• W2753639045 cites W1891473619 @default.
• W2753639045 cites W1965396574 @default.
• W2753639045 cites W1969689748 @default.
• W2753639045 cites W1977946740 @default.
• W2753639045 cites W1979442081 @default.
• W2753639045 cites W1988963904 @default.
• W2753639045 cites W1990874746 @default.
• W2753639045 cites W2000371172 @default.
• W2753639045 cites W2013074264 @default.
• W2753639045 cites W2016453697 @default.
• W2753639045 cites W2021231316 @default.
• W2753639045 cites W2030809692 @default.
• W2753639045 cites W2035788663 @default.
• W2753639045 cites W2036614700 @default.
• W2753639045 cites W2047045561 @default.
• W2753639045 cites W2049991241 @default.
• W2753639045 cites W2051572996 @default.
• W2753639045 cites W2055623470 @default.
• W2753639045 cites W2063503143 @default.
• W2753639045 cites W2063524276 @default.
• W2753639045 cites W2064420223 @default.
• W2753639045 cites W2069318845 @default.
• W2753639045 cites W2089921203 @default.
• W2753639045 cites W2093768281 @default.
• W2753639045 cites W2096307509 @default.
• W2753639045 cites W2103065322 @default.
• W2753639045 cites W2106621092 @default.
• W2753639045 cites W2107871548 @default.
• W2753639045 cites W2124226000 @default.
• W2753639045 cites W2126934950 @default.
• W2753639045 cites W2127013930 @default.
• W2753639045 cites W2127315472 @default.
• W2753639045 cites W2129727050 @default.
• W2753639045 cites W2133101176 @default.
• W2753639045 cites W2133564956 @default.
• W2753639045 cites W2140384407 @default.
• W2753639045 cites W2143210482 @default.
• W2753639045 cites W2143411481 @default.
• W2753639045 cites W2148446876 @default.
• W2753639045 cites W2149976637 @default.
• W2753639045 cites W2155159495 @default.
• W2753639045 cites W2158266834 @default.
• W2753639045 cites W2163005000 @default.
• W2753639045 cites W2166319880 @default.
• W2753639045 cites W2168152994 @default.
• W2753639045 cites W2192536572 @default.
• W2753639045 cites W2288026276 @default.
• W2753639045 cites W2322332255 @default.
• W2753639045 cites W2322471444 @default.
• W2753639045 cites W2327827971 @default.
• W2753639045 cites W2328176404 @default.
• W2753639045 cites W2333694147 @default.
• W2753639045 cites W2341392271 @default.
• W2753639045 cites W2558270198 @default.
• W2753639045 cites W2561503638 @default.
• W2753639045 cites W2565733028 @default.
• W2753639045 cites W2568161123 @default.
• W2753639045 cites W2624342213 @default.
• W2753639045 cites W4210980497 @default.
• W2753639045 cites W4232262676 @default.
• W2753639045 cites W4234633082 @default.
• W2753639045 cites W4239510810 @default.
• W2753639045 doi "https://doi.org/10.1371/journal.pntd.0005882" @default.
• W2753639045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5600393" @default.
• W2753639045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28873423" @default.
• W2753639045 hasPublicationYear "2017" @default.
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