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- W2753641792 abstract "Nanoparticles (NPs) are included in many products of daily life and present in the environment. Due to the potential of NPs to improve quality and stability of consumer and health and medical products, it is expected that the exposure of humans to engineered NPs will rather increase than decrease in the future. Although NPs did not act acutely cytotoxic on these concentrations, they may cause adverse effects upon chronic exposure. Cytotoxicity testing in long-term cultures and analysis of organelle function could identify such effects. Cells take up NPs mainly via active mechanisms, and these routes deliver their payload predominantly to lysosomes. Acute exposure of cells to NPs can have adverse effects on lysosome morphology and function, but lysosomes are also potential targets for accumulation. The chapter explains the role of lysosomes and describes techniques for labeling and assessment of their function. Examples for co-localization studies and vital dye staining are shown. A variety of techniques are available to characterize effects of NPs on lysosomes, but care has to be taken in the choice of the proper technique because NPs may interfere with the detection." @default.
- W2753641792 created "2017-09-15" @default.
- W2753641792 creator A5038414635 @default.
- W2753641792 date "2017-08-30" @default.
- W2753641792 modified "2023-10-16" @default.
- W2753641792 title "Cellular Screening Methods for the Study of Nanoparticle- Induced Lysosomal Damage" @default.
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- W2753641792 doi "https://doi.org/10.5772/intechopen.69306" @default.
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