FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2753642727> ?p ?o ?g. }

• W2753642727 endingPage "1396" @default.
• W2753642727 startingPage "1386" @default.
• W2753642727 abstract "Evidence indicates that increases in sympathetic nervous activity (SNA), and acclimatization to high altitude (HA), may reduce endothelial function as assessed by brachial artery flow-mediated dilatation (FMD); however, it is unclear whether such changes in FMD are due to direct vascular constraint, or consequential altered hemodynamics (e.g., shear stress) associated with increased SNA as a consequence of exposure to HA. We hypothesized that 1) at rest, SNA would be elevated and FMD would be reduced at HA compared with sea-level (SL); and 2) at SL and HA, FMD would be reduced when SNA was acutely increased, and elevated when SNA was acutely decreased. Using a novel, randomized experimental design, brachial artery FMD was assessed at SL (344 m) and HA (5,050 m) in 14 participants during mild lower-body negative pressure (LBNP; −10 mmHg) and lower-body positive pressure (LBPP; +10 mmHg). Blood pressure (finger photoplethysmography), heart rate (electrocardiogram), oxygen saturation (pulse oximetry), and brachial artery blood flow and shear rate (Duplex ultrasound) were recorded during LBNP, control, and LBPP trials. Muscle SNA was recorded (via microneurography) in a subset of participants ( n = 5). Our findings were 1) at rest, SNA was elevated ( P < 0.01), and absolute FMD was reduced ( P = 0.024), but relative FMD remained unaltered ( P = 0.061), at HA compared with SL; and 2) despite significantly altering SNA with LBNP (+60.3 ± 25.5%) and LBPP (−37.2 ± 12.7%) ( P < 0.01), FMD was unaltered at SL ( P = 0.448) and HA ( P = 0.537). These data indicate that acute and mild changes in SNA do not directly influence brachial artery FMD at SL or HA. NEW & NOTEWORTHY The role of the sympathetic nervous system on endothelial function remains unclear. We used lower-body negative and positive pressure to manipulate sympathetic nervous activity at sea level and high altitude and measured brachial endothelial function via flow-mediated dilation. We found that acutely altering sympathetic nervous activity had no effect on endothelial function." @default.
• W2753642727 created "2017-09-15" @default.
• W2753642727 creator A5005489723 @default.
• W2753642727 creator A5008416730 @default.
• W2753642727 creator A5011464170 @default.
• W2753642727 creator A5019530113 @default.
• W2753642727 creator A5021471472 @default.
• W2753642727 creator A5026126938 @default.
• W2753642727 creator A5040809163 @default.
• W2753642727 creator A5061777904 @default.
• W2753642727 creator A5062862146 @default.
• W2753642727 creator A5065805547 @default.
• W2753642727 date "2017-11-01" @default.
• W2753642727 modified "2023-10-16" @default.
• W2753642727 title "UBC-Nepal Expedition: acute alterations in sympathetic nervous activity do not influence brachial artery endothelial function at sea level and high altitude" @default.
• W2753642727 cites W1181763511 @default.
• W2753642727 cites W1529500123 @default.
• W2753642727 cites W1577098428 @default.
• W2753642727 cites W1806578306 @default.
• W2753642727 cites W1892687428 @default.
• W2753642727 cites W1932059163 @default.
• W2753642727 cites W1975215257 @default.
• W2753642727 cites W1979675693 @default.
• W2753642727 cites W1979807766 @default.
• W2753642727 cites W1982490079 @default.
• W2753642727 cites W1987447695 @default.
• W2753642727 cites W1998785099 @default.
• W2753642727 cites W2003803897 @default.
• W2753642727 cites W2007816704 @default.
• W2753642727 cites W2015051259 @default.
• W2753642727 cites W2018863700 @default.
• W2753642727 cites W2038772374 @default.
• W2753642727 cites W2049723014 @default.
• W2753642727 cites W2051149965 @default.
• W2753642727 cites W2061158982 @default.
• W2753642727 cites W2069490874 @default.
• W2753642727 cites W2072376419 @default.
• W2753642727 cites W2076769721 @default.
• W2753642727 cites W2076854554 @default.
• W2753642727 cites W2096993905 @default.
• W2753642727 cites W2100054266 @default.
• W2753642727 cites W2102156448 @default.
• W2753642727 cites W2103474165 @default.
• W2753642727 cites W2103507421 @default.
• W2753642727 cites W2105859544 @default.
• W2753642727 cites W2110085208 @default.
• W2753642727 cites W21131016 @default.
• W2753642727 cites W2113381282 @default.
• W2753642727 cites W2125078269 @default.
• W2753642727 cites W2125116040 @default.
• W2753642727 cites W2130164862 @default.
• W2753642727 cites W2135542263 @default.
• W2753642727 cites W2141522309 @default.
• W2753642727 cites W2141922649 @default.
• W2753642727 cites W2148825730 @default.
• W2753642727 cites W2155065403 @default.
• W2753642727 cites W2157425903 @default.
• W2753642727 cites W2160996511 @default.
• W2753642727 cites W2161309228 @default.
• W2753642727 cites W2165372850 @default.
• W2753642727 cites W2166977140 @default.
• W2753642727 cites W2181663293 @default.
• W2753642727 cites W2195919129 @default.
• W2753642727 cites W2212834047 @default.
• W2753642727 cites W2269928201 @default.
• W2753642727 cites W2338638760 @default.
• W2753642727 cites W2530342822 @default.
• W2753642727 cites W2555465797 @default.
• W2753642727 cites W2559007131 @default.
• W2753642727 cites W2583663683 @default.
• W2753642727 cites W62145855 @default.
• W2753642727 doi "https://doi.org/10.1152/japplphysiol.00583.2017" @default.
• W2753642727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5792096" @default.
• W2753642727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28860174" @default.
• W2753642727 hasPublicationYear "2017" @default.
• W2753642727 type Work @default.
• W2753642727 sameAs 2753642727 @default.
• W2753642727 citedByCount "14" @default.
• W2753642727 countsByYear W27536427272018 @default.
• W2753642727 countsByYear W27536427272019 @default.
• W2753642727 countsByYear W27536427272020 @default.
• W2753642727 countsByYear W27536427272021 @default.
• W2753642727 countsByYear W27536427272022 @default.
• W2753642727 countsByYear W27536427272023 @default.
• W2753642727 crossrefType "journal-article" @default.
• W2753642727 hasAuthorship W2753642727A5005489723 @default.
• W2753642727 hasAuthorship W2753642727A5008416730 @default.
• W2753642727 hasAuthorship W2753642727A5011464170 @default.
• W2753642727 hasAuthorship W2753642727A5019530113 @default.
• W2753642727 hasAuthorship W2753642727A5021471472 @default.
• W2753642727 hasAuthorship W2753642727A5026126938 @default.
• W2753642727 hasAuthorship W2753642727A5040809163 @default.
• W2753642727 hasAuthorship W2753642727A5061777904 @default.
• W2753642727 hasAuthorship W2753642727A5062862146 @default.
• W2753642727 hasAuthorship W2753642727A5065805547 @default.
• W2753642727 hasBestOaLocation W27536427271 @default.
• W2753642727 hasConcept C105702510 @default.
• W2753642727 hasConcept C106131492 @default.

• next