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- W2753644520 abstract "A genome-wide association study identified LMO1, which encodes an LIM-domain-only transcriptional cofactor, as a neuroblastoma susceptibility gene that functions as an oncogene in high-risk neuroblastoma. Here we show that dβh promoter-mediated expression of LMO1 in zebrafish synergizes with MYCN to increase the proliferation of hyperplastic sympathoadrenal precursor cells, leading to a reduced latency and increased penetrance of neuroblastomagenesis. The transgenic expression of LMO1 also promoted hematogenous dissemination and distant metastasis, which was linked to neuroblastoma cell invasion and migration, and elevated expression levels of genes affecting tumor cell-extracellular matrix interaction, including loxl3, itga2b, itga3, and itga5. Our results provide in vivo validation of LMO1 as an important oncogene that promotes neuroblastoma initiation, progression, and widespread metastatic dissemination." @default.
- W2753644520 created "2017-09-15" @default.
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- W2753644520 date "2017-09-01" @default.
- W2753644520 modified "2023-10-18" @default.
- W2753644520 title "LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis" @default.
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- W2753644520 doi "https://doi.org/10.1016/j.ccell.2017.08.002" @default.
- W2753644520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5605802" @default.
- W2753644520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28867147" @default.
- W2753644520 hasPublicationYear "2017" @default.