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- W2753648521 abstract "Objective To investigate the apoptosis of meningioma cell and changes of the expression of c-myc protooncogene after gama ray radiation.Methods The isolated and cultured meningioma cells with stable growth were obtained from a patient with meningiomas by mechanical separation,and those cells were divided into 4 groups with the radiation center doses of 2.00,5.00,8.22,and 13.33 Gy respectively.There was a control group without radiation.Meningioma cell morphology was observed under fluorescent microscope.Flow cytometry was used to examine the cell cycle and apoptosis.The expression of c-myc protein was detected by using Western blotting.Results The cell apoptosis rate in contol group,and radiation 2.00,5.00,8.22 and 13.22 Gy groups was respectively (3.73 ± 0.25) ％,(4.07 ± 0.29) ％,(9.81 ± 1.66)％,(21.63 ±3.08)％ and (8.27 ± 1.61)％.Ehe expression of c-myc protein in contol group,and radiation 2.00,5.00,8.22 and 13.22 Gy groups was respectively 0.11 ± 0.01,0.12 ± 0.01,0.19 ±0.02,0.31 ±0.08 and 0.09 ±0.01.There was no significant difference in the cell morphology,cell cycle,apoptosis and the expression of c-myc protein between control group and irradiation 2.00 Gy group.Characteristics of apoptosis were found in radiation 5.00 Gy and 8.22 Gy groups,and the number of cells in G0/G1 and G2/M phases was gradually increased as well as the apoptosis rate,and the c-myc protein expression increased (P ＜ 0.05) in radiation 5.00 and 8.22 Gy groups vs.control group.In irradiation 13.33 Gy group,necrosis was found widely,the number of cells in S phase was increased and the expression of c-myc protein decreased.Conclusion The apoptosis of meningioma cells could be induced by appropriate gamma ray dose.In this process,the c-myc proto-oncogene may promote the apoptosis of meningioma cells.Key words: Meningioma; Gamma-ray ; Cell cycle ; Apoptosis ; c-myc" @default.
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- W2753648521 date "2013-11-08" @default.
- W2753648521 modified "2023-09-27" @default.
- W2753648521 title "Effects of gamma-ray on apoptosis and expression of c-myc protooncogene of meningioma cells" @default.
- W2753648521 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2013.11.028" @default.
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