FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2753648768> ?p ?o ?g. }

• W2753648768 endingPage "321" @default.
• W2753648768 startingPage "311" @default.
• W2753648768 abstract "Cannabinoid Receptor Interacting Protein isoform 1b (CRIP1b) is known to interact with the CB1 receptor. Alternative splicing of the CNRIP1 gene produces CRIP1a and CRIP1b with a difference in the third exon only. Exons 1 and 2 encode for a functional domain in both proteins. CRIP1a is involved in regulating CB1 receptor internalization, but the function of CRIP1b is not very well characterized. Since there are significant identities in functional domains of these proteins, CRIP1b is a potential target for drug discovery. We report here predicted structure of CRIP1b followed by its interaction analysis with CB1 receptor by in-silico methods A number of complementary computational techniques, including, homology modeling, ab-initio and protein threading, were applied to generate three-dimensional molecular models for CRIP1b. The computed model of CRIP1b was refined, followed by docking with C terminus of CB1 receptor to generate a model for the CRIP1b- CB1 receptor interaction. The structure of CRIP1b obtained by homology modelling using RHO_GDI-2 as template is a sandwich fold structure having beta sheets connected by loops, similar to predicted CRIP1a structure. The best scoring refined model of CRIP1b in complex with the CB1 receptor C terminus peptide showed favourable polar interactions. The overall binding pocket of CRIP1b was found to be overlapping to that of CRIP1a. The Arg82 and Cys126 of CRIP1b are involved in the majority of hydrogen bond interactions with the CB1 receptor and are possible key residues required for interactions between the CB1 receptor and CRIP1b." @default.
• W2753648768 created "2017-09-15" @default.
• W2753648768 creator A5007502609 @default.
• W2753648768 creator A5015356306 @default.
• W2753648768 creator A5029100778 @default.
• W2753648768 creator A5043722479 @default.
• W2753648768 date "2017-10-01" @default.
• W2753648768 modified "2023-10-02" @default.
• W2753648768 title "In silico interaction analysis of cannabinoid receptor interacting protein 1b (CRIP1b) – CB1 cannabinoid receptor" @default.
• W2753648768 cites W1502369243 @default.
• W2753648768 cites W1845171218 @default.
• W2753648768 cites W1966345796 @default.
• W2753648768 cites W1968051797 @default.
• W2753648768 cites W1968430567 @default.
• W2753648768 cites W1969621320 @default.
• W2753648768 cites W1976499671 @default.
• W2753648768 cites W1976521702 @default.
• W2753648768 cites W1978304263 @default.
• W2753648768 cites W1978847105 @default.
• W2753648768 cites W1980374511 @default.
• W2753648768 cites W1987134040 @default.
• W2753648768 cites W1987474460 @default.
• W2753648768 cites W1996444783 @default.
• W2753648768 cites W1999613945 @default.
• W2753648768 cites W2001069120 @default.
• W2753648768 cites W2005750609 @default.
• W2753648768 cites W2013734705 @default.
• W2753648768 cites W2015324838 @default.
• W2753648768 cites W2016049391 @default.
• W2753648768 cites W2018292685 @default.
• W2753648768 cites W2026478054 @default.
• W2753648768 cites W2027487364 @default.
• W2753648768 cites W2027837654 @default.
• W2753648768 cites W2036149515 @default.
• W2753648768 cites W2037312364 @default.
• W2753648768 cites W2049902088 @default.
• W2753648768 cites W2051210555 @default.
• W2753648768 cites W2053350126 @default.
• W2753648768 cites W2053538195 @default.
• W2753648768 cites W2058206198 @default.
• W2753648768 cites W2060259273 @default.
• W2753648768 cites W2061543974 @default.
• W2753648768 cites W2080186237 @default.
• W2753648768 cites W2087894810 @default.
• W2753648768 cites W2090105394 @default.
• W2753648768 cites W2096495474 @default.
• W2753648768 cites W2099886875 @default.
• W2753648768 cites W2102105330 @default.
• W2753648768 cites W2102124048 @default.
• W2753648768 cites W2106342289 @default.
• W2753648768 cites W2110869427 @default.
• W2753648768 cites W2112924959 @default.
• W2753648768 cites W2114145026 @default.
• W2753648768 cites W2115167726 @default.
• W2753648768 cites W2116977569 @default.
• W2753648768 cites W2129954993 @default.
• W2753648768 cites W2131123685 @default.
• W2753648768 cites W2131900949 @default.
• W2753648768 cites W2139582206 @default.
• W2753648768 cites W2145268834 @default.
• W2753648768 cites W2152301430 @default.
• W2753648768 cites W2153983456 @default.
• W2753648768 cites W2154019529 @default.
• W2753648768 cites W2155201844 @default.
• W2753648768 cites W2161344628 @default.
• W2753648768 cites W2295500554 @default.
• W2753648768 cites W2323889349 @default.
• W2753648768 cites W2417106369 @default.
• W2753648768 cites W2510676695 @default.
• W2753648768 cites W2520865586 @default.
• W2753648768 cites W2558194266 @default.
• W2753648768 cites W2565813493 @default.
• W2753648768 cites W2598063798 @default.
• W2753648768 cites W2725622653 @default.
• W2753648768 doi "https://doi.org/10.1016/j.jmgm.2017.09.006" @default.
• W2753648768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5816684" @default.
• W2753648768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28918320" @default.
• W2753648768 hasPublicationYear "2017" @default.
• W2753648768 type Work @default.
• W2753648768 sameAs 2753648768 @default.
• W2753648768 citedByCount "8" @default.
• W2753648768 countsByYear W27536487682019 @default.
• W2753648768 countsByYear W27536487682021 @default.
• W2753648768 countsByYear W27536487682022 @default.
• W2753648768 countsByYear W27536487682023 @default.
• W2753648768 crossrefType "journal-article" @default.
• W2753648768 hasAuthorship W2753648768A5007502609 @default.
• W2753648768 hasAuthorship W2753648768A5015356306 @default.
• W2753648768 hasAuthorship W2753648768A5029100778 @default.
• W2753648768 hasAuthorship W2753648768A5043722479 @default.
• W2753648768 hasBestOaLocation W27536487682 @default.
• W2753648768 hasConcept C104317684 @default.
• W2753648768 hasConcept C135285700 @default.
• W2753648768 hasConcept C148001335 @default.
• W2753648768 hasConcept C159110408 @default.
• W2753648768 hasConcept C169627665 @default.
• W2753648768 hasConcept C170493617 @default.
• W2753648768 hasConcept C181199279 @default.

• next