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• W2753702102 abstract "Higher serum periostin concentrations are associated with mortality after head trauma. We further determined the relationship between periostin concentrations, severity, and clinical outcome in patients with intracerebral hemorrhage (ICH). We prospectively included 128 controls and 128 consecutive patients with acute ICH within the first 24 h after onset. At admission, we measured serum periostin concentrations. Serum periostin concentrations were significantly higher in the patients than in the controls. Serum periostin concentrations were positively related to National Institutes of Health Stroke Scale (NIHSS) score (r = 0.526) and hematoma volume (r = 0.586). An unfavorable outcome (defined as modified Rankin scale > 2) was observed in 65 (50.8%) patients. Serum periostin [odds ratio (OR), 1.008; 95% confidence interval (CI), 1.002–1.013], NIHSS score (OR, 1.462; 95% CI, 1.209–1.767), hematoma volume (OR, 1.134; 95% CI, 1.047–1.227) and age (OR, 1.060; 95% CI, 1.015–1.108) emerged as independent predictors for 6-month unfavorable outcome. In terms of ROC AUC, serum periostin concentrations had significantly higher predictive value compared with age and showed similar predictive value compared with NIHSS score and hematoma volume. High concentrations of serum periostin in acute ICH patients are associated with increasing severity and a poor functional prognosis." @default.
• W2753702102 created "2017-09-15" @default.
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• W2753702102 date "2017-11-01" @default.
• W2753702102 modified "2023-10-18" @default.
• W2753702102 title "Association between serum periostin concentrations and outcome after acute spontaneous intracerebral hemorrhage" @default.
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• W2753702102 doi "https://doi.org/10.1016/j.cca.2017.09.002" @default.
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