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- W2753725049 abstract "Abstract The Yamanaka factors convert mouse embryonic fibroblasts (MEFs) into induced pluripotent stem cells (iPSCs) through a highly heterogeneous process. Here we profile single cells undergoing an optimized 7-day reprogramming process and show that cells start reprogramming relatively in sync, but diverge into two branches around day 2. The first branch of cells expressing Cd34/Fxyd5/Psca become nonpluripotent. The second one contains cells that are first Oct4 +, then Dppa5a + and pluripotent. We show that IFN-γ blocks this late transition. Our results reveal the heterogeneous nature of somatic cell reprogramming, identify Dppa5a as a marker for pluripotent and innate immunity as a potential barrier for reprogramming. One Sentence Summary Single cell RNA sequencing reveals a continuum of cell fates from somatic to pluripotent and Dppa5a as a marker for chimera-competent iPSCs." @default.
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- W2753725049 date "2017-08-30" @default.
- W2753725049 modified "2023-10-05" @default.
- W2753725049 title "Resolution of Reprogramming Transition States by Single Cell RNA-Sequencing" @default.
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- W2753725049 doi "https://doi.org/10.1101/182535" @default.
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