FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2753733842> ?p ?o ?g. }

• W2753733842 endingPage "286" @default.
• W2753733842 startingPage "275" @default.
• W2753733842 abstract "Acacia nilotica (L.) Delile is used as a traditional anti-diabetic remedy in Bangladesh, Pakistan, Egypt, Nigeria and is mentioned in Ayurveda as well. The objective of the study was to evaluate the ethnomedicinal claim of A. nilotica leaf (ANL) extract for its efficiency in ameliorating diabetic complications. ANL was orally administrated (50 and 200 mg/kg) to alloxanized mice (blood glucose > 200 mg/dL) for 20 d. Parameters of glucose metabolism, hepatotoxicity, hyperlipidemia and nephrotoxicity were measured with emphasis on elevated oxidative stress. ANL was chemically characterized using GC-MS. Further, docking studies were employed to predict molecular interactions. ANL lowered (65%, P< 0.001) systemic glucose load in diabetic mice, which was otherwise 398% higher than control. ANL lowered (35%) insulin resistance, without any significant effect on insulin sensitivity (P> 0.05). Anti-hyperglycemic properties of ANL was further supported by lowering of HbA1c (34%; P< 0.001) and improved glucose utilization (OGTT). Overall diabetic complications were mitigated as reflected by lowered hepatic (ALT, AST) and renal (creatinine, BUN) injury markers and normalization of dyslipidemia. Elevated systemic oxidative stress was lowered by increased catalase and peroxidase activities in liver, kidney and skeletal muscle, resulting in 32% decrease of serum MDA levels. Apart from high phenolic and flavonoid content, tocopherol, catechol and β-sitosterol, identified in ANL, demonstrated substantial binding affinity with Nrf2 protein (5FNQ) reflecting possible crosstalk with intracellular antioxidant defense pathways. The present study revealed the potentials of A. nilotica to alleviate diabetes-related systemic complications by limiting oxidative stress which justified the ethnopharmacological antidiabetic claim." @default.
• W2753733842 created "2017-09-15" @default.
• W2753733842 creator A5020245054 @default.
• W2753733842 creator A5033664171 @default.
• W2753733842 creator A5044299388 @default.
• W2753733842 creator A5054616714 @default.
• W2753733842 creator A5069076680 @default.
• W2753733842 creator A5073823019 @default.
• W2753733842 creator A5076494122 @default.
• W2753733842 date "2018-01-01" @default.
• W2753733842 modified "2023-09-26" @default.
• W2753733842 title "Acacia nilotica leaf improves insulin resistance and hyperglycemia associated acute hepatic injury and nephrotoxicity by improving systemic antioxidant status in diabetic mice" @default.
• W2753733842 cites W1021878384 @default.
• W2753733842 cites W1508167383 @default.
• W2753733842 cites W1589953995 @default.
• W2753733842 cites W1767659454 @default.
• W2753733842 cites W1949907771 @default.
• W2753733842 cites W1965085919 @default.
• W2753733842 cites W1973631125 @default.
• W2753733842 cites W1975067867 @default.
• W2753733842 cites W1975536395 @default.
• W2753733842 cites W1990949451 @default.
• W2753733842 cites W1992797115 @default.
• W2753733842 cites W1994201341 @default.
• W2753733842 cites W1997013634 @default.
• W2753733842 cites W2000999406 @default.
• W2753733842 cites W2002046476 @default.
• W2753733842 cites W2008480928 @default.
• W2753733842 cites W2010472426 @default.
• W2753733842 cites W2025485770 @default.
• W2753733842 cites W2028037324 @default.
• W2753733842 cites W2028265515 @default.
• W2753733842 cites W2035083444 @default.
• W2753733842 cites W2035861988 @default.
• W2753733842 cites W2038809517 @default.
• W2753733842 cites W2044778099 @default.
• W2753733842 cites W2051354670 @default.
• W2753733842 cites W2053356284 @default.
• W2753733842 cites W2057811513 @default.
• W2753733842 cites W2058310563 @default.
• W2753733842 cites W2060365040 @default.
• W2753733842 cites W2064119981 @default.
• W2753733842 cites W2065579593 @default.
• W2753733842 cites W2080875615 @default.
• W2753733842 cites W2088012387 @default.
• W2753733842 cites W2091641501 @default.
• W2753733842 cites W2093521563 @default.
• W2753733842 cites W2095014707 @default.
• W2753733842 cites W2098012175 @default.
• W2753733842 cites W2099025649 @default.
• W2753733842 cites W2105731956 @default.
• W2753733842 cites W2110857736 @default.
• W2753733842 cites W2117800935 @default.
• W2753733842 cites W2118688616 @default.
• W2753733842 cites W2120535614 @default.
• W2753733842 cites W2122623396 @default.
• W2753733842 cites W2126327417 @default.
• W2753733842 cites W2127923665 @default.
• W2753733842 cites W2129387684 @default.
• W2753733842 cites W2146764931 @default.
• W2753733842 cites W2148109667 @default.
• W2753733842 cites W2150898264 @default.
• W2753733842 cites W2160234571 @default.
• W2753733842 cites W2164564813 @default.
• W2753733842 cites W2171439919 @default.
• W2753733842 cites W2211420666 @default.
• W2753733842 cites W2259682376 @default.
• W2753733842 cites W2294679918 @default.
• W2753733842 cites W2318873431 @default.
• W2753733842 cites W2402015540 @default.
• W2753733842 cites W2517888724 @default.
• W2753733842 cites W2534048118 @default.
• W2753733842 cites W2539340921 @default.
• W2753733842 cites W2546893782 @default.
• W2753733842 cites W2603237362 @default.
• W2753733842 cites W4240986128 @default.
• W2753733842 cites W4248107770 @default.
• W2753733842 cites W4252826951 @default.
• W2753733842 cites W840875033 @default.
• W2753733842 doi "https://doi.org/10.1016/j.jep.2017.08.036" @default.
• W2753733842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28859934" @default.
• W2753733842 hasPublicationYear "2018" @default.
• W2753733842 type Work @default.
• W2753733842 sameAs 2753733842 @default.
• W2753733842 citedByCount "31" @default.
• W2753733842 countsByYear W27537338422018 @default.
• W2753733842 countsByYear W27537338422019 @default.
• W2753733842 countsByYear W27537338422020 @default.
• W2753733842 countsByYear W27537338422021 @default.
• W2753733842 countsByYear W27537338422022 @default.
• W2753733842 countsByYear W27537338422023 @default.
• W2753733842 crossrefType "journal-article" @default.
• W2753733842 hasAuthorship W2753733842A5020245054 @default.
• W2753733842 hasAuthorship W2753733842A5033664171 @default.
• W2753733842 hasAuthorship W2753733842A5044299388 @default.
• W2753733842 hasAuthorship W2753733842A5054616714 @default.
• W2753733842 hasAuthorship W2753733842A5069076680 @default.
• W2753733842 hasAuthorship W2753733842A5073823019 @default.

• next