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- W2753775178 abstract "Autism spectrum disorder (ASD) is a neurodevelopmental disorder often associated with changes in structural structure of the brain. Researchers posit that these core features may be underpinned by disrupted structural connectivity. The current study aimed to investigate diffusion characteristics of autism using diffusion tensor imaging (DTI), which is neuroimaging method that allows us to examine the structure and integrity of these white matter tracts, serebellum and nucleus accumbens. Our study group consisted of 40 autism and 40 age-matched controls. We analyzed diffusion characteristics of preselected WM bundles: corpus callosum (CC), uncinate fasciculus (UF), arcuate fasciculus (AF). We measured fractional anisotropy (FA) for CC and FA for other bundles. The ASD had lower FA in CC, right CIN, right AF and right UF but higher FA in left CIN and left AF. FA of left UF is a similarly in both of groups. However the differences were not statistically significant. The total number of fibers was larger in the left AF, left UF in ASD however the differences did not show any significance between the groups. Our findings suggest that ASD could affect WM architecture. The findings need to be confirmed on a larger population." @default.
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- W2753775178 date "2017-06-01" @default.
- W2753775178 modified "2023-10-12" @default.
- W2753775178 title "Analyzing autism spectrum disorder with structural and diffusion magnetic resonance imaging in white matter, nucleus accumens and cerebellum" @default.
- W2753775178 doi "https://doi.org/10.1016/j.ejpn.2017.04.1293" @default.
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