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- W2753808505 abstract "Background: Homeopathy is a medical system based on the principle of “like cures like”. It involves the use of natural substances that can cause a similar illness in a healthy person to stimulate the healing process. Homeopathic medicines use an ultra-diluted concentration of substances, which cannot be measured; therefore, their effectiveness is a matter of debate. Methods: To prove the effectiveness of homeopathic remedies, mRNA and protein expression of cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines were evaluated using RT-PCR and immunoblotting in primary cultured mouse chondrocytes and pre-osteoblastic MC3T3-e1 cells stimulated with a homeopathic dilution of Rhus toxicodendron. Results: COX-2mRNA and protein were highly expressed in both chondrocytes and MC3T3-e1 cells stimulated with Rhus toxicodendron. Conclusion: Rhus toxicodendron has been used as a homeopathic medicine to ameliorate arthritic pain and to modulate inflammatory conditions. During the inflammatory process, COX-2 is upregulated, which subsequently increases prostaglandin E2 production. Homeopathic dilution of Rhus toxicodendron increased COX-2 mRNA and protein expression, as confirmed by RT-PCR and immunoblotting. This study provides a unique approach for establishing the effectiveness of homeopathy; however, further studies are needed to examine the exact cellular signaling mechanisms." @default.
- W2753808505 created "2017-09-15" @default.
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- W2753808505 date "2016-08-29" @default.
- W2753808505 modified "2023-09-26" @default.
- W2753808505 title "Proving the Effectiveness of Homeopathic Remedy Using a Cell-based System" @default.
- W2753808505 doi "https://doi.org/10.15344/2456-8007/2016/107" @default.
- W2753808505 hasPublicationYear "2016" @default.
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