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- W2753912808 abstract "Candida albicans is the most important medically relevant fungal pathogen, with disseminated candidiasis being the fourth most common hospital-associated bloodstream infection. Macrophages and neutrophils are innate immune cells that play a key role in host defense by phagocytosing and destroying C. albicans cells. To survive this attack by macrophages, C. albicans generates energy by utilizing alternative carbon sources that are available in the phagosome. Interestingly, metabolism of amino acids and carboxylic acids by C. albicans raises the pH of the phagosome and thereby blocks the acidification of the phagosome, which is needed to initiate antimicrobial attack. In this work, we demonstrate that metabolism of a third type of carbon source, the amino sugar GlcNAc, also induces pH neutralization and survival of C. albicans upon phagocytosis. This mechanism is genetically and physiologically distinct from the previously described mechanisms of pH neutralization, indicating that the robust metabolic plasticity of C. albicans ensures survival upon macrophage phagocytosis." @default.
- W2753912808 created "2017-09-15" @default.
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- W2753912808 date "2017-10-25" @default.
- W2753912808 modified "2023-09-26" @default.
- W2753912808 title "<i>N</i> -Acetylglucosamine Metabolism Promotes Survival of Candida albicans in the Phagosome" @default.
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- W2753912808 doi "https://doi.org/10.1128/msphere.00357-17" @default.
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