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• W2753932519 abstract "There is clear evidence that achieving glycaemic targets reduces the risk of developing complications as a result of type 2 diabetes (T2D). Many patients, however, continue to have suboptimal glycaemic control because of issues that include unclear advice on how to achieve these targets as well as clinical inertia. The two management approaches recommended for patients newly diagnosed with T2D are stepwise and combination therapy, each of which has advantages and disadvantages. Stepwise therapy may result in good patient adherence and allow greater individualization of therapy, and minimization of side effects and cost, and so may be appropriate for patients who are closer to goal. Stepwise therapy, however, may also lead to frequent delays in achieving glycaemic goals and longer exposure to hyperglycaemia. Combination therapy, which is now emerging as an important therapy option, has a number of potential advantages over stepwise therapy, including reduction in clinical inertia and earlier and more frequent achievement of glycated haemoglobin goals by targeting multiple pathogenic mechanisms simultaneously, which may more effectively delay disease progression. Compared with stepwise therapy, the disadvantages of combination therapy include reduced patient adherence resulting from complex, multi‐drug regimens, difficulty determining the cause of poor efficacy and/or side effects, patient refusal to accept disease, and higher cost. Fixed‐dose and fixed‐ratio combinations are novel therapeutic approaches which may help address several issues of treatment complexity and patient burden associated with combination therapy comprising individual drugs. The choice of which drugs to administer and the decision to use stepwise vs combination therapy, however, should always be made on an individualized basis." @default.
• W2753932519 created "2017-09-15" @default.
• W2753932519 creator A5034091030 @default.
• W2753932519 creator A5037572670 @default.
• W2753932519 creator A5063808837 @default.
• W2753932519 creator A5079024626 @default.
• W2753932519 date "2017-10-02" @default.
• W2753932519 modified "2023-10-01" @default.
• W2753932519 title "Initiating therapy in patients newly diagnosed with type 2 diabetes: Combination therapy vs a stepwise approach" @default.
• W2753932519 cites W1550770032 @default.
• W2753932519 cites W1576760610 @default.
• W2753932519 cites W172609984 @default.
• W2753932519 cites W1752045965 @default.
• W2753932519 cites W1752565673 @default.
• W2753932519 cites W1908117496 @default.
• W2753932519 cites W1972329806 @default.
• W2753932519 cites W1975663485 @default.
• W2753932519 cites W1981706606 @default.
• W2753932519 cites W1981713709 @default.
• W2753932519 cites W1985772842 @default.
• W2753932519 cites W1987067408 @default.
• W2753932519 cites W1988447828 @default.
• W2753932519 cites W1989325640 @default.
• W2753932519 cites W1990008846 @default.
• W2753932519 cites W1990994987 @default.
• W2753932519 cites W1997746831 @default.
• W2753932519 cites W2007221722 @default.
• W2753932519 cites W2009830637 @default.
• W2753932519 cites W2020827332 @default.
• W2753932519 cites W2022773701 @default.
• W2753932519 cites W2029228033 @default.
• W2753932519 cites W2031195667 @default.
• W2753932519 cites W2031542147 @default.
• W2753932519 cites W2033283875 @default.
• W2753932519 cites W2039966938 @default.
• W2753932519 cites W2041375230 @default.
• W2753932519 cites W2050153005 @default.
• W2753932519 cites W2058569680 @default.
• W2753932519 cites W2060716197 @default.
• W2753932519 cites W2067533175 @default.
• W2753932519 cites W2070309137 @default.
• W2753932519 cites W2078860212 @default.
• W2753932519 cites W2084204099 @default.
• W2753932519 cites W2087910657 @default.
• W2753932519 cites W2088113192 @default.
• W2753932519 cites W2090447931 @default.
• W2753932519 cites W2091977092 @default.
• W2753932519 cites W2095218046 @default.
• W2753932519 cites W2102487069 @default.
• W2753932519 cites W2105744242 @default.
• W2753932519 cites W2107834306 @default.
• W2753932519 cites W2109728760 @default.
• W2753932519 cites W2114102308 @default.
• W2753932519 cites W2116286254 @default.
• W2753932519 cites W2117349244 @default.
• W2753932519 cites W2123946565 @default.
• W2753932519 cites W2126862523 @default.
• W2753932519 cites W2137471483 @default.
• W2753932519 cites W2141001773 @default.
• W2753932519 cites W2143044822 @default.
• W2753932519 cites W2143413851 @default.
• W2753932519 cites W2143724691 @default.
• W2753932519 cites W2146264128 @default.
• W2753932519 cites W2147262642 @default.
• W2753932519 cites W2147602249 @default.
• W2753932519 cites W2147743786 @default.
• W2753932519 cites W2152289419 @default.
• W2753932519 cites W2156941386 @default.
• W2753932519 cites W2160088494 @default.
• W2753932519 cites W2160461278 @default.
• W2753932519 cites W2171294019 @default.
• W2753932519 cites W2172193326 @default.
• W2753932519 cites W2188846692 @default.
• W2753932519 cites W2189221254 @default.
• W2753932519 cites W2191315196 @default.
• W2753932519 cites W2220809980 @default.
• W2753932519 cites W2222692848 @default.
• W2753932519 cites W2226954704 @default.
• W2753932519 cites W2273894627 @default.
• W2753932519 cites W2278329651 @default.
• W2753932519 cites W2292172438 @default.
• W2753932519 cites W2346635432 @default.
• W2753932519 cites W2366221926 @default.
• W2753932519 cites W2411222006 @default.
• W2753932519 cites W2425644022 @default.
• W2753932519 cites W2444268874 @default.
• W2753932519 cites W2482897222 @default.
• W2753932519 cites W2491672698 @default.
• W2753932519 cites W2500979702 @default.
• W2753932519 cites W2506990877 @default.
• W2753932519 cites W2507901651 @default.
• W2753932519 cites W2514766623 @default.
• W2753932519 cites W2519704960 @default.
• W2753932519 cites W2519803668 @default.
• W2753932519 cites W2521422828 @default.
• W2753932519 cites W2568525643 @default.
• W2753932519 cites W2577436930 @default.
• W2753932519 cites W2592811846 @default.

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