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- W2753943169 abstract "Introduction: Chromatin remodeling complexes play important roles in the control of genome regulation in both normal and diseased states, and are therefore critical components for the regulation of epigenetic states in cells. Given the role epigenetics plays in cancer, for example, chromatin remodeling complexes are routinely targeted for therapeutic intervention.Areas covered: Protein mass spectrometry and proteomics are powerful technologies used to study and understand chromatin remodeling. While impressive progress has been made in this area, there remain significant challenges in the application of proteomic technologies to the study of chromatin remodeling. As parts of large multi-subunit complexes that can be heavily modified with dynamic post-translational modifications, challenges in the study of chromatin remodeling complexes include defining the content, determining the regulation, and studying the dynamics of the complexes under different cellular states.Expert commentary: Impwortant considerations in the study of chromatin remodeling complexes include the complexity of sample preparation, the choice of proteomic methods for the analysis of samples, and data analysis challenges. Continued research in these three areas promise to yield even greater insights into the biology of chromatin remodeling and epigenetics and the dynamics of these systems in human health and cancer." @default.
- W2753943169 created "2017-09-25" @default.
- W2753943169 creator A5021750799 @default.
- W2753943169 creator A5034566006 @default.
- W2753943169 creator A5053051067 @default.
- W2753943169 creator A5072539599 @default.
- W2753943169 date "2017-09-20" @default.
- W2753943169 modified "2023-10-17" @default.
- W2753943169 title "Unravelling the biology of chromatin in health and cancer using proteomic approaches" @default.
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