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- W2753992783 startingPage "1035" @default.
- W2753992783 abstract "Protein-depleted states generate allosteric inhibition of liver cystathionine β-synthase (CBS), which governs the first enzymatic step of the transsulfuration cascade, resulting in upstream accretion of homocysteine (Hcy) in body fluids. A similar Hcy increase may arise from normal hepatocytes undergoing experimentally-induced impairment of betaine-homocysteine methyltransferase (BHTM) activity or from components of lean body mass (LBM) submitted to any inflammatory disorder. LBM comprises a composite agglomeration of extrarenal tissues characterized by naturally occurring BHTM inactivity. As a result of cellular injury, LBM releases high concentrations of Hcy into the extracellular space, contrasting with the disruption of normal remethylation pathways. Hyperhomocysteinemia acts as a biomarker, reflecting the severity of insult and operating as an alarm signal. Elevated Hcy levels constitute a precursor pool recognized by a CBS coding region that reacts to meet increased methionine requirements in LBM tissues, using its enhanced production in hepatocytes. Preservation of methionine homeostasis benefits from its high metabolic priority and survival value." @default.
- W2753992783 created "2017-09-25" @default.
- W2753992783 creator A5033684580 @default.
- W2753992783 date "2017-09-20" @default.
- W2753992783 modified "2023-10-16" @default.
- W2753992783 title "Lean Body Mass Harbors Sensing Mechanisms that Allow Safeguarding of Methionine Homeostasis" @default.
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