Matches in SemOpenAlex for { <https://semopenalex.org/work/W2754003109> ?p ?o ?g. }
- W2754003109 endingPage "10454" @default.
- W2754003109 startingPage "10449" @default.
- W2754003109 abstract "Significance Invariant natural killer T (iNKT) cells recognize lipid antigens in the context of CD1d and have potent effects on immunity. Control of iNKT cells is critical to prevent inflammation, but the mechanisms that maintain homeostasis of iNKT cells in peripheral tissues are incompletely understood. Here we demonstrate that hepatocytes promote the apoptosis of local, liver-resident iNKT cells in a manner dependent on CD1d. In the absence of hepatocyte CD1d or microsomal triglyceride transfer protein, a protein responsible for lipid transfer onto CD1d, hepatic iNKT cell numbers are increased, which is associated with susceptibility to iNKT cell-dependent hepatitis. This work thus reveals a pathway of peripheral induction of immune tolerance, which limits susceptibility to iNKT cell-dependent inflammation in the liver." @default.
- W2754003109 created "2017-09-25" @default.
- W2754003109 creator A5001285437 @default.
- W2754003109 creator A5024979380 @default.
- W2754003109 creator A5031900006 @default.
- W2754003109 creator A5032954959 @default.
- W2754003109 creator A5050963621 @default.
- W2754003109 creator A5053599868 @default.
- W2754003109 creator A5054599656 @default.
- W2754003109 creator A5083421637 @default.
- W2754003109 date "2017-09-11" @default.
- W2754003109 modified "2023-10-17" @default.
- W2754003109 title "CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation" @default.
- W2754003109 cites W1537132972 @default.
- W2754003109 cites W1949861316 @default.
- W2754003109 cites W1968141301 @default.
- W2754003109 cites W1970777915 @default.
- W2754003109 cites W1975137285 @default.
- W2754003109 cites W1988932163 @default.
- W2754003109 cites W1989478912 @default.
- W2754003109 cites W1995856733 @default.
- W2754003109 cites W1996424780 @default.
- W2754003109 cites W2003747312 @default.
- W2754003109 cites W2008688211 @default.
- W2754003109 cites W2012582093 @default.
- W2754003109 cites W2026647673 @default.
- W2754003109 cites W2038904723 @default.
- W2754003109 cites W2040120039 @default.
- W2754003109 cites W2044306159 @default.
- W2754003109 cites W2048438175 @default.
- W2754003109 cites W2063400663 @default.
- W2754003109 cites W2063441372 @default.
- W2754003109 cites W2064794064 @default.
- W2754003109 cites W2073343574 @default.
- W2754003109 cites W2076024275 @default.
- W2754003109 cites W2080062279 @default.
- W2754003109 cites W2080898127 @default.
- W2754003109 cites W2085116778 @default.
- W2754003109 cites W2104585015 @default.
- W2754003109 cites W2106047742 @default.
- W2754003109 cites W2106322659 @default.
- W2754003109 cites W2106992467 @default.
- W2754003109 cites W2116390941 @default.
- W2754003109 cites W2124073536 @default.
- W2754003109 cites W2127022761 @default.
- W2754003109 cites W2141770821 @default.
- W2754003109 cites W2148077170 @default.
- W2754003109 cites W2149878896 @default.
- W2754003109 cites W2153416566 @default.
- W2754003109 cites W2159081962 @default.
- W2754003109 cites W2167281612 @default.
- W2754003109 cites W2179234980 @default.
- W2754003109 cites W2233778785 @default.
- W2754003109 cites W4244017533 @default.
- W2754003109 cites W64458079 @default.
- W2754003109 doi "https://doi.org/10.1073/pnas.1701428114" @default.
- W2754003109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5625893" @default.
- W2754003109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28893990" @default.
- W2754003109 hasPublicationYear "2017" @default.
- W2754003109 type Work @default.
- W2754003109 sameAs 2754003109 @default.
- W2754003109 citedByCount "21" @default.
- W2754003109 countsByYear W27540031092018 @default.
- W2754003109 countsByYear W27540031092019 @default.
- W2754003109 countsByYear W27540031092020 @default.
- W2754003109 countsByYear W27540031092021 @default.
- W2754003109 countsByYear W27540031092022 @default.
- W2754003109 countsByYear W27540031092023 @default.
- W2754003109 crossrefType "journal-article" @default.
- W2754003109 hasAuthorship W2754003109A5001285437 @default.
- W2754003109 hasAuthorship W2754003109A5024979380 @default.
- W2754003109 hasAuthorship W2754003109A5031900006 @default.
- W2754003109 hasAuthorship W2754003109A5032954959 @default.
- W2754003109 hasAuthorship W2754003109A5050963621 @default.
- W2754003109 hasAuthorship W2754003109A5053599868 @default.
- W2754003109 hasAuthorship W2754003109A5054599656 @default.
- W2754003109 hasAuthorship W2754003109A5083421637 @default.
- W2754003109 hasBestOaLocation W27540031091 @default.
- W2754003109 hasConcept C13028836 @default.
- W2754003109 hasConcept C134018914 @default.
- W2754003109 hasConcept C139563560 @default.
- W2754003109 hasConcept C202751555 @default.
- W2754003109 hasConcept C203014093 @default.
- W2754003109 hasConcept C2776090121 @default.
- W2754003109 hasConcept C2776200302 @default.
- W2754003109 hasConcept C2776914184 @default.
- W2754003109 hasConcept C2778163477 @default.
- W2754003109 hasConcept C2778607024 @default.
- W2754003109 hasConcept C2780072125 @default.
- W2754003109 hasConcept C55493867 @default.
- W2754003109 hasConcept C63645605 @default.
- W2754003109 hasConcept C8243546 @default.
- W2754003109 hasConcept C86803240 @default.
- W2754003109 hasConcept C8891405 @default.
- W2754003109 hasConcept C95444343 @default.
- W2754003109 hasConceptScore W2754003109C13028836 @default.
- W2754003109 hasConceptScore W2754003109C134018914 @default.
- W2754003109 hasConceptScore W2754003109C139563560 @default.