Matches in SemOpenAlex for { <https://semopenalex.org/work/W2754014788> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2754014788 endingPage "186" @default.
- W2754014788 startingPage "179" @default.
- W2754014788 abstract "Background: Endometrial cancer is a common gynecological malignancy with good prognosis in the early stages of the disease. The CpG island in the promoter region of tumor-suppressor genes are frequently methylated in various types of human cancers. In the present study, we have examined the methylation status of the p16INK4a and p14ARF genes in endometrial cancer and healthy endometrium with the aim to identify correlations between promoter hypermethylation, disease risk, and clinicopathological parameters.Methods: We collected 28 formalin fixed paraffin embedded samples and 26 blood samples from endometrial cancer patients and 22 controls. Methylation-specific PCR was applied to analyze the promoter methylation status of the p16INK4a and p14ARF genes in the studied population. The results were analyzed with SPSS software version 20.Results: There was a significant difference between the study groups and the presence of promoter CpG hypermethylation status in the p14 (P<0.0001) and p16 (P<0.05) genes. p14 hypermethylation in the blood samples was associated with depth of myometrial invasion in endometrial cancer (P=0.03). A significant association existed between p16methylation in tissue with endometrial cancer grade (P=0.06). No statistically significant difference existed between the p16INK4a and p14ARF promoter hypermethylations in blood (P=0.177) and formalin fixed paraffin embedded (P=0.221) samples. An association existed between p16INK4a and p14ARF gene hypermethylations in blood and tissue with diabetes.Conclusion: Our results have confirmed that epigenetic mechanisms play an important role in endometrial cancer incidence. They can be utilized as prognostic biomarkers for endometrial cancer. The lack of a significant difference between the p16INK4a and p14ARF promoter hypermethylations in blood and formalin fixed paraffin embedded samples has indicated that methylation status of a blood sample can be an early, non-invasive diagnostic marker in endometrial cancer." @default.
- W2754014788 created "2017-09-25" @default.
- W2754014788 creator A5011609815 @default.
- W2754014788 creator A5018241606 @default.
- W2754014788 date "2017-10-01" @default.
- W2754014788 modified "2023-09-28" @default.
- W2754014788 title "Evaluation of Promoter Hypermethylation of Tumor-Suppressor Genes p14 and p16 in Iranian Endometrial Carcinoma Patients" @default.
- W2754014788 hasPublicationYear "2017" @default.
- W2754014788 type Work @default.
- W2754014788 sameAs 2754014788 @default.
- W2754014788 citedByCount "0" @default.
- W2754014788 crossrefType "journal-article" @default.
- W2754014788 hasAuthorship W2754014788A5011609815 @default.
- W2754014788 hasAuthorship W2754014788A5018241606 @default.
- W2754014788 hasConcept C101762097 @default.
- W2754014788 hasConcept C104317684 @default.
- W2754014788 hasConcept C121608353 @default.
- W2754014788 hasConcept C126322002 @default.
- W2754014788 hasConcept C140173407 @default.
- W2754014788 hasConcept C143998085 @default.
- W2754014788 hasConcept C150194340 @default.
- W2754014788 hasConcept C190727270 @default.
- W2754014788 hasConcept C2776750431 @default.
- W2754014788 hasConcept C2777088508 @default.
- W2754014788 hasConcept C2777546739 @default.
- W2754014788 hasConcept C2778264664 @default.
- W2754014788 hasConcept C2908647359 @default.
- W2754014788 hasConcept C33288867 @default.
- W2754014788 hasConcept C41091548 @default.
- W2754014788 hasConcept C502942594 @default.
- W2754014788 hasConcept C54355233 @default.
- W2754014788 hasConcept C555283112 @default.
- W2754014788 hasConcept C71924100 @default.
- W2754014788 hasConcept C86803240 @default.
- W2754014788 hasConcept C99454951 @default.
- W2754014788 hasConceptScore W2754014788C101762097 @default.
- W2754014788 hasConceptScore W2754014788C104317684 @default.
- W2754014788 hasConceptScore W2754014788C121608353 @default.
- W2754014788 hasConceptScore W2754014788C126322002 @default.
- W2754014788 hasConceptScore W2754014788C140173407 @default.
- W2754014788 hasConceptScore W2754014788C143998085 @default.
- W2754014788 hasConceptScore W2754014788C150194340 @default.
- W2754014788 hasConceptScore W2754014788C190727270 @default.
- W2754014788 hasConceptScore W2754014788C2776750431 @default.
- W2754014788 hasConceptScore W2754014788C2777088508 @default.
- W2754014788 hasConceptScore W2754014788C2777546739 @default.
- W2754014788 hasConceptScore W2754014788C2778264664 @default.
- W2754014788 hasConceptScore W2754014788C2908647359 @default.
- W2754014788 hasConceptScore W2754014788C33288867 @default.
- W2754014788 hasConceptScore W2754014788C41091548 @default.
- W2754014788 hasConceptScore W2754014788C502942594 @default.
- W2754014788 hasConceptScore W2754014788C54355233 @default.
- W2754014788 hasConceptScore W2754014788C555283112 @default.
- W2754014788 hasConceptScore W2754014788C71924100 @default.
- W2754014788 hasConceptScore W2754014788C86803240 @default.
- W2754014788 hasConceptScore W2754014788C99454951 @default.
- W2754014788 hasIssue "4" @default.
- W2754014788 hasLocation W27540147881 @default.
- W2754014788 hasOpenAccess W2754014788 @default.
- W2754014788 hasPrimaryLocation W27540147881 @default.
- W2754014788 hasRelatedWork W1964017123 @default.
- W2754014788 hasRelatedWork W1978839542 @default.
- W2754014788 hasRelatedWork W2040469213 @default.
- W2754014788 hasRelatedWork W2045002992 @default.
- W2754014788 hasRelatedWork W2170183176 @default.
- W2754014788 hasRelatedWork W2348129716 @default.
- W2754014788 hasRelatedWork W2349152365 @default.
- W2754014788 hasRelatedWork W2353609762 @default.
- W2754014788 hasRelatedWork W2356657729 @default.
- W2754014788 hasRelatedWork W2358447883 @default.
- W2754014788 hasRelatedWork W2375679170 @default.
- W2754014788 hasRelatedWork W2377784466 @default.
- W2754014788 hasRelatedWork W2393781933 @default.
- W2754014788 hasRelatedWork W2783109906 @default.
- W2754014788 hasRelatedWork W287394440 @default.
- W2754014788 hasRelatedWork W3024437505 @default.
- W2754014788 hasRelatedWork W3030002324 @default.
- W2754014788 hasRelatedWork W3128728257 @default.
- W2754014788 hasRelatedWork W3192645241 @default.
- W2754014788 hasRelatedWork W3204366723 @default.
- W2754014788 hasVolume "8" @default.
- W2754014788 isParatext "false" @default.
- W2754014788 isRetracted "false" @default.
- W2754014788 magId "2754014788" @default.
- W2754014788 workType "article" @default.