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• W2754063074 abstract "Abstract Marine viruses are major evolutionary and biogeochemical drivers of microbial life in the ocean. Host response to viral infection typically includes virus-induced rewiring of metabolic network to supply essential building blocks for viral assembly, as opposed to activation of anti-viral host defense. Nevertheless, there is a major bottleneck to accurately discern between viral hijacking strategies and host defense responses when averaging bulk population response. Here we use Emiliania huxleyi , a bloom-forming alga and its specific virus (EhV), as one of the most ecologically important host-virus model system in the ocean. Using automatic microfluidic setup to capture individual algal cells, we quantified host and virus gene expression on a single-cell resolution during the course of infection. We revealed high heterogeneity in viral gene expression among individual cells. Simultaneous measurements of expression profiles of host and virus genes at a single-cell level allowed mapping of infected cells into newly defined infection states and uncover a yet unrecognized early phase in host response that occurs prior to viral expression. Intriguingly, resistant cells emerged during viral infection, showed unique expression profiles of metabolic genes which can provide the basis for discerning between viral resistant and sensitive cells within heterogeneous populations in the marine environment. We propose that resolving host-virus arms race at a single-cell level will provide important mechanistic insights into viral life cycles and will uncover host defense strategies." @default.
• W2754063074 created "2017-09-25" @default.
• W2754063074 creator A5008891275 @default.
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• W2754063074 date "2017-09-12" @default.
• W2754063074 modified "2023-09-23" @default.
• W2754063074 title "Unmasking cellular response of a bloom-forming alga to virus infection by resolving expression profiling at a single-cell level" @default.
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• W2754063074 doi "https://doi.org/10.1101/186981" @default.
• W2754063074 hasPublicationYear "2017" @default.
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