Matches in SemOpenAlex for { <https://semopenalex.org/work/W2754127042> ?p ?o ?g. }
- W2754127042 endingPage "973" @default.
- W2754127042 startingPage "961" @default.
- W2754127042 abstract "Background There has been increasing evidence that chronic low-grade inflammation is associated with mood disorders. However, the findings have been inconsistent because of heterogeneity across studies and methodological limitations. Our aim is to prospectively evaluate the bi-directional associations between inflammatory markers including interleukin (IL)-6, tumor necrosis factor (TNF)- α and high sensitivity C-reactive protein (hsCRP) with mood disorders. Methods The sample consisted of 3118 participants (53.7% women; mean age: 51.0, s.d. 8.8 years), randomly selected from the general population, who underwent comprehensive somatic and psychiatric evaluations at baseline and follow-up (mean follow-up duration = 5.5 years, s.d. 0.6). Current and remitted mood disorders including bipolar and major depressive disorders (MDD) and its subtypes (atypical, melancholic, combined atypical and melancholic, and unspecified) were based on semi-structured diagnostic interviews. Inflammatory biomarkers were analyzed in fasting blood samples. Associations were tested by multiple linear and logistic regression models. Results Current combined MDD [ β = 0.29, 95% confidence interval (CI) 0.03–0.55] and current atypical MDD ( β = 0.32, 95% CI 0.10–0.55) at baseline were associated with increased levels of hsCRP at follow-up. There was little evidence for inflammation markers at baseline predicting mood disorders at follow-up. Conclusions The prospective unidirectional association between current MDD subtype with atypical features and hsCRP levels at follow-up suggests that inflammation may be a consequence of this condition. The role of inflammation, particularly hsCRP that is critically involved in cardiovascular diseases, warrants further study. Future research that examines potential influences of medications on inflammatory processes is indicated." @default.
- W2754127042 created "2017-09-25" @default.
- W2754127042 creator A5001329325 @default.
- W2754127042 creator A5003654686 @default.
- W2754127042 creator A5027210624 @default.
- W2754127042 creator A5028256346 @default.
- W2754127042 creator A5029276983 @default.
- W2754127042 creator A5037140624 @default.
- W2754127042 creator A5040882968 @default.
- W2754127042 creator A5044262070 @default.
- W2754127042 creator A5047797878 @default.
- W2754127042 creator A5057279591 @default.
- W2754127042 creator A5071050491 @default.
- W2754127042 creator A5071616414 @default.
- W2754127042 creator A5085842876 @default.
- W2754127042 creator A5085895517 @default.
- W2754127042 date "2017-09-20" @default.
- W2754127042 modified "2023-10-17" @default.
- W2754127042 title "Mood disorders and circulating levels of inflammatory markers in a longitudinal population-based study" @default.
- W2754127042 cites W1964002523 @default.
- W2754127042 cites W1966111889 @default.
- W2754127042 cites W1968294774 @default.
- W2754127042 cites W1973788838 @default.
- W2754127042 cites W1974702488 @default.
- W2754127042 cites W1983099697 @default.
- W2754127042 cites W1985438873 @default.
- W2754127042 cites W1986031269 @default.
- W2754127042 cites W1990824174 @default.
- W2754127042 cites W1992470868 @default.
- W2754127042 cites W1992955066 @default.
- W2754127042 cites W1995618636 @default.
- W2754127042 cites W1997115145 @default.
- W2754127042 cites W2001689304 @default.
- W2754127042 cites W2006418886 @default.
- W2754127042 cites W2006771204 @default.
- W2754127042 cites W2007116949 @default.
- W2754127042 cites W2014435820 @default.
- W2754127042 cites W2014746025 @default.
- W2754127042 cites W2022545037 @default.
- W2754127042 cites W2023453911 @default.
- W2754127042 cites W2023560341 @default.
- W2754127042 cites W2024951540 @default.
- W2754127042 cites W2033541273 @default.
- W2754127042 cites W2034630933 @default.
- W2754127042 cites W2049413394 @default.
- W2754127042 cites W2051133719 @default.
- W2754127042 cites W2052533964 @default.
- W2754127042 cites W2054009000 @default.
- W2754127042 cites W2056755341 @default.
- W2754127042 cites W2062820049 @default.
- W2754127042 cites W2076098977 @default.
- W2754127042 cites W2078160072 @default.
- W2754127042 cites W2079969776 @default.
- W2754127042 cites W2082279387 @default.
- W2754127042 cites W2084079665 @default.
- W2754127042 cites W2084199772 @default.
- W2754127042 cites W2085881951 @default.
- W2754127042 cites W2087451203 @default.
- W2754127042 cites W2091741871 @default.
- W2754127042 cites W2092608768 @default.
- W2754127042 cites W2094591316 @default.
- W2754127042 cites W2107764058 @default.
- W2754127042 cites W2110065044 @default.
- W2754127042 cites W2122921864 @default.
- W2754127042 cites W2135398815 @default.
- W2754127042 cites W2138875667 @default.
- W2754127042 cites W2142710692 @default.
- W2754127042 cites W2148132316 @default.
- W2754127042 cites W2148792199 @default.
- W2754127042 cites W2156698817 @default.
- W2754127042 cites W2157242620 @default.
- W2754127042 cites W2157739644 @default.
- W2754127042 cites W2158218002 @default.
- W2754127042 cites W2159036260 @default.
- W2754127042 cites W2163092745 @default.
- W2754127042 cites W2329541771 @default.
- W2754127042 cites W2528385426 @default.
- W2754127042 doi "https://doi.org/10.1017/s0033291717002744" @default.
- W2754127042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28929992" @default.
- W2754127042 hasPublicationYear "2017" @default.
- W2754127042 type Work @default.
- W2754127042 sameAs 2754127042 @default.
- W2754127042 citedByCount "35" @default.
- W2754127042 countsByYear W27541270422019 @default.
- W2754127042 countsByYear W27541270422020 @default.
- W2754127042 countsByYear W27541270422021 @default.
- W2754127042 countsByYear W27541270422022 @default.
- W2754127042 countsByYear W27541270422023 @default.
- W2754127042 crossrefType "journal-article" @default.
- W2754127042 hasAuthorship W2754127042A5001329325 @default.
- W2754127042 hasAuthorship W2754127042A5003654686 @default.
- W2754127042 hasAuthorship W2754127042A5027210624 @default.
- W2754127042 hasAuthorship W2754127042A5028256346 @default.
- W2754127042 hasAuthorship W2754127042A5029276983 @default.
- W2754127042 hasAuthorship W2754127042A5037140624 @default.
- W2754127042 hasAuthorship W2754127042A5040882968 @default.
- W2754127042 hasAuthorship W2754127042A5044262070 @default.
- W2754127042 hasAuthorship W2754127042A5047797878 @default.