Matches in SemOpenAlex for { <https://semopenalex.org/work/W2754150489> ?p ?o ?g. }
- W2754150489 endingPage "111" @default.
- W2754150489 startingPage "100" @default.
- W2754150489 abstract "Extracellular vesicles released from cancer cells may play an important role in cancer progression by shuttling oncogenic information into recipient cells. However, our knowledge is still fragmentary and there remain numerous questions regarding the mechanisms at play and the functional consequences of these interactions. We have recently established a mesenchymal-like prostate cancer cell line (22Rv1/CR-1; Mes-PCa). In this study, we assessed the effects of the extracellular vesicles released by these cells on recipient androgen-dependent epithelial VCaP prostate cancer cells. Mes-PCa derived vesicles were found to promote mesenchymal features in the recipient epithelial-like prostate cancer cells. This transformation was accompanied by a modulation of androgen receptor signaling and activation of TGFβ signaling pathway. Moreover, recipient cells acquiring mesenchymal traits displayed enhanced migratory and invasive features as well as increased resistance to the androgen receptor antagonist, enzalutamide. Our results suggest a previously unappreciated role for Mes-PCa secreted vesicles in cancer promotion by transferring cell-mediated signals and promoting phenotypic changes in recipient prostate cancer cells." @default.
- W2754150489 created "2017-09-25" @default.
- W2754150489 creator A5010007370 @default.
- W2754150489 creator A5011214982 @default.
- W2754150489 creator A5011774200 @default.
- W2754150489 creator A5014270123 @default.
- W2754150489 creator A5016447331 @default.
- W2754150489 creator A5027890396 @default.
- W2754150489 creator A5034581425 @default.
- W2754150489 creator A5034635531 @default.
- W2754150489 creator A5039991590 @default.
- W2754150489 creator A5061975059 @default.
- W2754150489 creator A5073180895 @default.
- W2754150489 creator A5085797655 @default.
- W2754150489 creator A5089320369 @default.
- W2754150489 date "2017-12-01" @default.
- W2754150489 modified "2023-10-12" @default.
- W2754150489 title "Extracellular vesicles released by mesenchymal-like prostate carcinoma cells modulate EMT state of recipient epithelial-like carcinoma cells through regulation of AR signaling" @default.
- W2754150489 cites W1521364230 @default.
- W2754150489 cites W1522977578 @default.
- W2754150489 cites W1864918391 @default.
- W2754150489 cites W1898690520 @default.
- W2754150489 cites W1972741145 @default.
- W2754150489 cites W1982669563 @default.
- W2754150489 cites W1987012261 @default.
- W2754150489 cites W1997930286 @default.
- W2754150489 cites W2017896209 @default.
- W2754150489 cites W2027424913 @default.
- W2754150489 cites W2037742191 @default.
- W2754150489 cites W2038744035 @default.
- W2754150489 cites W2070188884 @default.
- W2754150489 cites W2072022331 @default.
- W2754150489 cites W2076356973 @default.
- W2754150489 cites W2080418767 @default.
- W2754150489 cites W2081124475 @default.
- W2754150489 cites W2097642044 @default.
- W2754150489 cites W2104171348 @default.
- W2754150489 cites W2113851421 @default.
- W2754150489 cites W2114032563 @default.
- W2754150489 cites W2119274522 @default.
- W2754150489 cites W2121158863 @default.
- W2754150489 cites W2123303153 @default.
- W2754150489 cites W2124156632 @default.
- W2754150489 cites W2134548024 @default.
- W2754150489 cites W2148790937 @default.
- W2754150489 cites W2157018554 @default.
- W2754150489 cites W2159810380 @default.
- W2754150489 cites W2159959302 @default.
- W2754150489 cites W2169491358 @default.
- W2754150489 cites W2181283187 @default.
- W2754150489 cites W2209832288 @default.
- W2754150489 cites W2235523093 @default.
- W2754150489 cites W2259481044 @default.
- W2754150489 cites W2266388180 @default.
- W2754150489 cites W2298006847 @default.
- W2754150489 cites W2314242122 @default.
- W2754150489 cites W2414581058 @default.
- W2754150489 cites W2597130646 @default.
- W2754150489 cites W4211233744 @default.
- W2754150489 cites W4235592864 @default.
- W2754150489 doi "https://doi.org/10.1016/j.canlet.2017.09.010" @default.
- W2754150489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28935391" @default.
- W2754150489 hasPublicationYear "2017" @default.
- W2754150489 type Work @default.
- W2754150489 sameAs 2754150489 @default.
- W2754150489 citedByCount "27" @default.
- W2754150489 countsByYear W27541504892018 @default.
- W2754150489 countsByYear W27541504892019 @default.
- W2754150489 countsByYear W27541504892020 @default.
- W2754150489 countsByYear W27541504892021 @default.
- W2754150489 countsByYear W27541504892022 @default.
- W2754150489 countsByYear W27541504892023 @default.
- W2754150489 crossrefType "journal-article" @default.
- W2754150489 hasAuthorship W2754150489A5010007370 @default.
- W2754150489 hasAuthorship W2754150489A5011214982 @default.
- W2754150489 hasAuthorship W2754150489A5011774200 @default.
- W2754150489 hasAuthorship W2754150489A5014270123 @default.
- W2754150489 hasAuthorship W2754150489A5016447331 @default.
- W2754150489 hasAuthorship W2754150489A5027890396 @default.
- W2754150489 hasAuthorship W2754150489A5034581425 @default.
- W2754150489 hasAuthorship W2754150489A5034635531 @default.
- W2754150489 hasAuthorship W2754150489A5039991590 @default.
- W2754150489 hasAuthorship W2754150489A5061975059 @default.
- W2754150489 hasAuthorship W2754150489A5073180895 @default.
- W2754150489 hasAuthorship W2754150489A5085797655 @default.
- W2754150489 hasAuthorship W2754150489A5089320369 @default.
- W2754150489 hasConcept C121608353 @default.
- W2754150489 hasConcept C198826908 @default.
- W2754150489 hasConcept C2776235491 @default.
- W2754150489 hasConcept C2776551883 @default.
- W2754150489 hasConcept C2779013556 @default.
- W2754150489 hasConcept C2780192828 @default.
- W2754150489 hasConcept C502942594 @default.
- W2754150489 hasConcept C54355233 @default.
- W2754150489 hasConcept C61367390 @default.
- W2754150489 hasConcept C76419328 @default.
- W2754150489 hasConcept C86803240 @default.
- W2754150489 hasConcept C95444343 @default.