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- W27541547 abstract "IL-6 mRNA is produced by Sertoli cells as well as by Leydig cells in primary cultures established from the testes of immature rats. This chapter presents data suggesting that Leydig cell-enriched cultures produce a stimulator of IL-6 and that induction by this factor occurs during the initial 18 hr in vitro. Human and rat testes produce a large amount of IL-1, and IL-1 is a potent inducer of IL-6 in a variety of cell types. Recent studies demonstrated that the production of IL-1 by rat Sertoli cells increased during sexual maturation. Therefore, it is likely that Leydig cells and Sertoli cells increase their expression of IL-6 mRNA by an endocrine, autocrine, and/or paracrine factor in parallel to sexual maturation. Sertoli cells and Leydig cells express IL-6 mRNAs in culture, and the expression of these mRNAs can be stimulated by several kinds of inducers. The testicular IL-6 gene expression is induced in somatic cells under noninflammatory states, and it has the potential to fulfill a paracrine/autocrine role in mediating interactions among different testicular cells." @default.
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- W27541547 date "1995-01-01" @default.
- W27541547 modified "2023-09-25" @default.
- W27541547 title "Interleukins-1α and -1β Regulate Interleukin-6 Expression in Leydig and Sertoli cells" @default.
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- W27541547 doi "https://doi.org/10.1016/b978-0-12-571150-0.50022-6" @default.
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