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- W2754166467 abstract "Lichen planus (LP) is a chronic T-cell-mediated mucocutaneous inflammatory disease that targets stratified epithelia, including those lining the oral cavity. The intraoral variant of LP (OLP) is associated with interferon (IFN)-γ production by infiltrating T lymphocytes; however, the role of epithelial cells in the etiopathogenesis OLP is not completely understood. There is however a growing body of evidence regarding the involvement of epithelial-derived cytokines, immune receptors, and costimulatory molecules in the pathobiological processes that promote and sustain OLP. In the present study, we used a reverse transcriptase-polymerase chain reaction assay to assess whether CD40—a receptor found mainly on antigen presenting cells—and the costimulatory molecule CD86 were expressed in oral keratinocytes (three strains of primary normal oral keratinocytes and the H357 cell line) in the presence or absence of IFN-γ. To further characterize the involvement of CD40 in OLP, expression and distribution of receptor and ligand (CD40/CD154) in tissues from OLP were evaluated by immunohistochemistry. The present results are the first to show that both CD40 and CD86 are constitutively expressed at low levels in oral keratinocytes and that their expression was enhanced by IFN-γ stimulation. The intensity of CD40 staining in OLP tissues was strong. Taken together, the results strongly suggest that CD40 and CD86 play a role in the pathophysiology of oral inflammatory diseases such as OLP." @default.
- W2754166467 created "2017-09-25" @default.
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- W2754166467 date "2017-01-01" @default.
- W2754166467 modified "2023-10-01" @default.
- W2754166467 title "Immune receptors CD40 and CD86 in oral keratinocytes and implications for oral lichen planus" @default.
- W2754166467 cites W1480456069 @default.
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- W2754166467 cites W1502521547 @default.
- W2754166467 cites W1505657283 @default.
- W2754166467 cites W1530044612 @default.
- W2754166467 cites W1552852054 @default.
- W2754166467 cites W1610027395 @default.
- W2754166467 cites W1610110459 @default.
- W2754166467 cites W1644827081 @default.
- W2754166467 cites W1843917399 @default.
- W2754166467 cites W1894653348 @default.
- W2754166467 cites W1926247556 @default.
- W2754166467 cites W1971572880 @default.
- W2754166467 cites W1974381902 @default.
- W2754166467 cites W1977123411 @default.
- W2754166467 cites W1978683506 @default.
- W2754166467 cites W1978883524 @default.
- W2754166467 cites W1979426030 @default.
- W2754166467 cites W1984902285 @default.
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- W2754166467 cites W2012913533 @default.
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- W2754166467 cites W2024855291 @default.
- W2754166467 cites W2025240311 @default.
- W2754166467 cites W2039832327 @default.
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- W2754166467 cites W2147226575 @default.
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- W2754166467 doi "https://doi.org/10.2334/josnusd.16-0334" @default.
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- W2754166467 hasPublicationYear "2017" @default.
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