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• W2754237624 abstract "Summary Hepatitis C virus ( HCV ) is a major cause of chronic hepatitis. Previous studies have identified a number of single nucleotide polymorphisms that are associated with HCV infection. Human platelet antigens ( HPA s) polymorphisms play an important role in several diseases. Here, we demonstrated the association of the HPA ‐2, HPA ‐3, HPA ‐5 and HPA ‐15 polymorphisms with susceptibility to HCV infection in Chinese population. Overall, 118 patients with HCV and 167 controls were genotyped for HPA s. There were no significant differences in the allele and genotype frequency distribution for the HPA ‐3, HPA ‐5 and HPA ‐15 systems between the patients with chronic HCV infection and the healthy controls ( p > .05). However, the genotype frequency of HPA ‐2aa was significantly lower, while HPA ‐2ab/bb was significantly higher in patients than that in the controls ( p = .006). The allele frequency of HPA ‐2a in patients was significantly lower than that in the control group ( p = .005). In contrast, HPA ‐2b in patients was significantly higher than that in the control group ( p = .005). We conclude that HPA ‐2 polymorphism is associated with susceptibility to HCV infection, and individuals carrying the HPA ‐2b allele may have a higher risk of HCV infection compared with individuals carrying HPA ‐2a." @default.
• W2754237624 created "2017-09-25" @default.
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• W2754237624 date "2017-09-20" @default.
• W2754237624 modified "2023-10-07" @default.
• W2754237624 title "Association of human platelet antigens polymorphisms with susceptibility to hepatitis C virus infection in Chinese population" @default.
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• W2754237624 doi "https://doi.org/10.1111/iji.12341" @default.
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