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- W2754294446 abstract "To identify, appraise and summarise the available data, concerning the real impact of HPV infection on the woman and the reproductive outcomes following in vitro fertilisation (IVF). We searched for studies on PubMed, Embase, Scopus, Lilacs and the Cochrane Central Register of Controlled Trials from inception to Mar-2017. Any type of HPV infection in the woman assessed through PCR, subfertility factors and IVF indications and protocols were considered. Our outcomes were live birth/ongoing pregnancy, clinical pregnancy and miscarriage. We assessed the relative risk (RR), using a random-effects model; heterogeneity was assessed by I2 statistics. The quality of the evidence was evaluated using the recommendations from GRADE working group. Data from eight studies evaluating 208 women with HPV infection and 965 women without HPV infection were included in the analyses. The pooled results showed no significant difference in live birth/ongoing pregnancy (RR=1.16, 95%CI=0.88-1.53, I2=0%, 6 studies, 983 women), clinical pregnancy (RR=1.06, 95%CI=0.74-1.54, I2=61%, 8 studies, 1173 women), and miscarriage rates (RR=1.58, 95%CI=0.93-2.69, I2=8%, 6 studies, 290 clinical pregnancies). The overall quality of the evidence was very low, downgraded two levels because of serious limitations of included studies (observational studies) and imprecision. The available evidence is still insufficient to conclude about the effect of the HPV infection of the woman have on the most important reproductive outcomes following IVF; however, it suggests that the effect (negative or positive) is not very large for live birth/ongoing pregnancy and clinical pregnancy rates." @default.
- W2754294446 created "2017-09-25" @default.
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- W2754294446 date "2017-09-01" @default.
- W2754294446 modified "2023-09-27" @default.
- W2754294446 title "P26.05: The possible effect of HPV infection on IVF outcomes: a systematic review and meta-analysis" @default.
- W2754294446 doi "https://doi.org/10.1002/uog.18264" @default.
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