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• W2754311144 endingPage "43" @default.
• W2754311144 startingPage "34" @default.
• W2754311144 abstract "Translesion synthesis (TLS) is the mechanism in which DNA polymerases (TLS polymerases) bypass unrepaired template damage with high error rates. DNA polymerase η and ζ (Polη and Polζ) are major TLS polymerases that are conserved from yeast to humans. In this study, we quantified frequencies of base-substitutions by yeast Polη and Polζ on undamaged and abasic templates in vitro. For accurate quantification, we used a next generation sequencing (NGS)-based method where DNA products were directly analyzed by parallel sequencing. On undamaged templates, Polη and Polζ showed distinct base-substitution profiles, and the substitution frequencies were differently influenced by the template sequence. The base-substitution frequencies were influenced mainly by the adjacent bases both upstream and downstream of the substitution sites. Thus we present the base-substitution signatures of these polymerases in a three-base format. On templates containing abasic sites, Polη created deletions at the lesion in more than 50% of the TLS products, but the formation of the deletions was suppressed by the presence of Polζ. Polζ and Polη cooperatively facilitated the TLS reaction over an abasic site in vitro, suggesting that these two polymerases can cooperate in efficient and high fidelity TLS." @default.
• W2754311144 created "2017-09-25" @default.
• W2754311144 creator A5061352298 @default.
• W2754311144 creator A5074825288 @default.
• W2754311144 date "2017-11-01" @default.
• W2754311144 modified "2023-09-26" @default.
• W2754311144 title "NGS-based analysis of base-substitution signatures created by yeast DNA polymerase eta and zeta on undamaged and abasic DNA templates in vitro" @default.
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• W2754311144 doi "https://doi.org/10.1016/j.dnarep.2017.08.011" @default.
• W2754311144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5643249" @default.
• W2754311144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28946034" @default.
• W2754311144 hasPublicationYear "2017" @default.
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