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- W2754361483 abstract "Abstract The reaction of homopiperazine with 2-trifluoroacetyl-1 H -benzo[ f ]chromenes affords 2-(1,5-diazabicyclo[3.2.1]octan-8-yl)-3-(trifluoromethyl)-2,3-dihydro-1 H -benzo[ f ]chromen-3-ols, while 3-trifluoroacetyl-4 H -chromenes give 2-[2-(1,5-diazabicyclo[3.2.1]octan-8-yl)ethyl]phenols. Both reactions are the first examples of synthesis of 1,5-diazabicyclo[3.2.1]octane core via double Michael addition and include cascade Michael addition/pyran ring opening/Michael addition." @default.
- W2754361483 created "2017-09-25" @default.
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- W2754361483 date "2017-10-01" @default.
- W2754361483 modified "2023-09-24" @default.
- W2754361483 title "Synthesis of 8-substituted 1,5-diazabicyclo[3.2.1]octane derivatives via double aza-Michael addition of homopiperazine to 3-trifluoroacetyl-4 H -chromenes" @default.
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- W2754361483 doi "https://doi.org/10.1016/j.jfluchem.2017.09.006" @default.
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