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• W2754371934 abstract "Carbon monoxide (CO) poisoning may cause significant toxicity to the central nervous system. This study aimed to evaluate the risk of epilepsy after CO poisoning with and without hyperbaric oxygen (HBO) therapy using nationwide database. We conducted a population-based cohort study and retrieved the patients with CO poisoning between 2000 and 2010. We included 8,264 patients with CO poisoning (1,917 patients, 23.20%, receiving HBO, and 6,347 patients, 76.80%, not receiving HBO) as the study cohort, and 41,320 matched patients without CO intoxication as the comparison cohort after matching for age, sex, and index year. Cox proportional hazards regression was conducted to evaluate the hazard ratios (HRs) of epilepsy in patients with CO poisoning. Baseline comorbidities, such as hypertension, hyperlipidemia, diabetes mellitus, coronary artery disease, stroke, and chronic obstructive pulmonary disease were identified and further adjusted. All patients were followed until a new diagnosis of epilepsy, death, or December 31, 2013. An association was identified between CO poisoning and subsequent epilepsy development after adjustment for potential confounders (adjusted HR: 8.40 (95% CI: 6.48-10.88), P<0.001). In subgroup analysis, the patients with CO poisoning who received HBO did not have an obviously increased HR to develop epilepsy than those who did not receive HBO (HR: 1.17 (95% CI: 0.81-1.69), P=0.395). In stratification analysis, the young patients with CO poisoning had an increased adjusted HR to develop epilepsy than the older patients (adjusted HR: 11.06 (95% CI: 7.17-17.08) in patients aged 20-39 years; adjusted HR: 8.53 (95% CI: 5.76-12.63) in patients aged 40-64 years). The Kaplan-Meier analysis (Figure 1) showed a higher IR for epilepsy in the CO poisoning patients compared with the patients without CO poisoning (Log-rank test, P<0.001). The patients with CO poisoning had an increased risk of epilepsy than the patients without CO poisoning, especially in young population. HBO may attenuate the risk of epilepsy in the patients with CO poisoning in long-term follow up." @default.
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• W2754371934 date "2017-10-01" @default.
• W2754371934 modified "2023-09-26" @default.
• W2754371934 title "319 Risk of Epilepsy After Carbon Monoxide Poisoning: A Nationwide Cohort Study" @default.
• W2754371934 doi "https://doi.org/10.1016/j.annemergmed.2017.07.390" @default.
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