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• W2754378608 abstract "In this study, the genotoxic potential of <50 nm, <100 nm iron oxide (Fe 2 O 3 ) nanoparticles (IONPs) and ionic form were investigated using the wing somatic mutation and recombination test (SMART) and Allium and comet assays. In the SMART assay, different concentrations (1, 2, 5 and 10 mM) of NPs and ionic forms were fed to transheterozygous larvae of Drosophila melanogaster. No significant genotoxic effect was observed in <100 nm NPs and ionic form, while <50 nm IONPs showed genotoxicity at 1 and 10 mM concentrations. Allium cepa root meristems were exposed to five concentrations (0.001, 0.01, 0.1, 1 and 10 mM) of <50 nm and ionic forms for 4 h and three concentrations (2.5, 5 and 10 mM) for <100 nm of IONPs for 24 and 96 h. There was a statistically significant effect at 96 h at all concentrations of <100 nm IONPs. Similarly, <50 nm of IONPs and ionic forms also showed a statistically significant effect on mitotic index frequencies for all concentrations at 4 h. There was a dose-dependent increase in chromosomal abnormalities for IONPs and ionic form. Comet assay results showed time- and concentration-dependent increases in <100 nm NPs. There was a concentration-dependent increase in <50 nm NPs and ionic form ( p < 0.05). Consequently, the <50 nm of Fe 2 O 3 was found toxic compared to 100 nm Fe 2 O 3 and ionic form." @default.
• W2754378608 created "2017-09-25" @default.
• W2754378608 creator A5039600480 @default.
• W2754378608 creator A5070343285 @default.
• W2754378608 date "2017-09-11" @default.
• W2754378608 modified "2023-10-16" @default.
• W2754378608 title "Genotoxic evaluation of different sizes of iron oxide nanoparticles and ionic form by SMART, Allium and comet assay" @default.
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• W2754378608 doi "https://doi.org/10.1177/0748233717722907" @default.
• W2754378608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28893155" @default.
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